Evidence map›Paper›PMID 30202009›Full record

ArticleNature communications2018

Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding.

Emma Lång, Anna Połeć, Anna Lång, Marijke Valk, Pernille Blicher, Alexander D Rowe, Kim A Tønseth, Catherine J Jackson, Tor P Utheim, Liesbeth M C Janssen and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Flocking and giant fluctuations in epithelial active solids.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Skin Microbiome: Current Landscape and Future Opportunities.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Emma LångDepartment of Medical Biochemistry, Oslo University Hospital, 0372, Oslo, Norway.
Anna PołećDepartment of Medical Biochemistry, Oslo University Hospital, 0372, Oslo, Norway.
Anna LångDepartment of Medical Biochemistry, Oslo University Hospital, 0372, Oslo, Norway.
Marijke ValkDepartment of Applied Physics, Eindhoven University of Technology, 5600 MB, Eindhoven, Netherlands.
Pernille BlicherDepartment of Medical Biochemistry, Institute of Clinical Medicine, University of Oslo, 0450, Oslo, Norway.
Alexander D RoweDepartment of Medical Biochemistry, Oslo University Hospital, 0372, Oslo, Norway.
Kim A TønsethDepartment of Plastic and Reconstructive Surgery, Oslo University Hospital, 0372, Oslo, Norway.
Catherine J JacksonDepartment of Medical Biochemistry, Oslo University Hospital, 0372, Oslo, Norway.
Tor P UtheimDepartment of Medical Biochemistry, Oslo University Hospital, 0372, Oslo, Norway.
Liesbeth M C JanssenDepartment of Applied Physics, Eindhoven University of Technology, 5600 MB, Eindhoven, Netherlands.
Jens ErikssonDepartment of Medical Biochemistry, Oslo University Hospital, 0372, Oslo, Norway.
Stig Ove BøeDepartment of Medical Biochemistry, Oslo University Hospital, 0372, Oslo, Norway. stig.ove.boe@rr-research.no.
Oslo University Hospital · NOEindhoven University of Technology · NLUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial sheet spreading is a fundamental cellular process that must be coordinated with cell division and differentiation to restore tissue integrity. Here we use consecutive serum deprivation and re-stimulation to reconstruct biphasic collective migration and proliferation in cultured sheets of human keratinocytes. In this system, a burst of long-range coordinated locomotion is rapidly generated throughout the cell sheet in the absence of wound edges. Migrating cohorts reach correlation lengths of several millimeters and display dependencies on epidermal growth factor receptor-mediated signaling, self-propelled polarized migration, and a G

Indexed as

Asymmetric Cell DivisionCell MovementCell DifferentiationCell DivisionCell Line, TumorCell PolarityCohort StudiesEpidermisEpitheliumErbB ReceptorsG1 PhaseHeLa CellsHumansKeratinocytesLysosomesMicroscopy, ConfocalErbB Receptors

Identifiers

PMID30202009
PMCPMC6131553
OpenAlexW2889800002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.