Evidence map›Paper›PMID 30201983›Full record

ArticleLeukemia2018

NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.

Morten Tulstrup, Marie Grosjean, Stine Nygaard Nielsen, Kathrine Grell, Benjamin Ole Wolthers, Peder Skov Wegener, Olafur Gisli Jonsson, Bendik Lund, Arja Harila-Saari, Jonas Abrahamsson and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Medical sciences (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 16 institutions in 8 countries.

Morten TulstrupDepartment of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7444-7652
Marie GrosjeanDepartment of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark.
Stine Nygaard NielsenDepartment of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Kathrine GrellDepartment of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Benjamin Ole WolthersDepartment of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Peder Skov WegenerDepartment of Pediatric Hematology and Oncology, H. C. Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Olafur Gisli JonssonDepartment of Pediatrics, Landspitali University Hospital, Reykjavík, Iceland.
Bendik LundDepartment of Pediatrics, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Arja Harila-SaariDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Jonas AbrahamssonDepartment of Pediatrics, Institution for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Goda VaitkevicieneClinic of Children's Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Kaie PruunsildDepartment of Onco-haematology, Talinn Children's Hospital, Talinn, Estonia.
Nina ToftDepartment of Hematology, University Hospital Rishospitalet, Copenhagen, Denmark.
Mette HolmDepartment of Haematology, Aarhus University Hospital, Aarhus, Denmark.
Erik HulegårdhDepartment of Hematology and Coagulation, Sahlgrenska University Hospital, Göteborg, Sweden.
Sigurd LiestølDepartment of Hematology, Ullevål University Hospital, Faculty Division Ullevål University Hospital, University of Oslo, Oslo, Norway.
Laimonas GriskeviciusInstitute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Mari PunabClinic of Hematology and Oncology, Tartu University Clinic, Tartu, Estonia.
Jinhua WangMasonic Cancer Center, Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
William L CarrollDepartment of Pediatrics, New York University Medical Center, Perlmutter Cancer Center, New York, NY, USA.
Zeyu ZhangDepartment of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark.
Marlene D DalgaardDepartment of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark.
Ramneek GuptaDepartment of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark.
Jacob NerstingDepartment of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.
Kjeld SchmiegelowDepartment of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark. kjeld.schmiegelow@regionh.dk.
Rigshospitalet · DKTechnical University of Denmark · DKUniversity of Copenhagen · DKVilnius University · LTAarhus University Hospital · DKNorwegian University of Science and Technology · NOOdense University Hospital · DKOslo University Hospital · NOReykjavík University · ISSahlgrenska University Hospital · SESino-Danish Centre for Education and Research · CNTartu University Hospital · EEUniversity Medical Center · USUniversity of Gothenburg · SEUniversity of Minnesota · USUppsala University · SE

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NCATS NIH HHS UL1 TR002494
6 · The paper itself

Abstract

The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a series of genome-wide association studies, we analysed time-weighted means (

Indexed as

5'-NucleotidaseAdolescentAntimetabolites, AntineoplasticChildChild, PreschoolDNAFemaleGene FrequencyGenome-Wide Association StudyGenotypeGerm CellsHumansInfantMaleMercaptopurineNeoplasm Recurrence, Local5'-NucleotidaseAntimetabolites, AntineoplasticDNAMercaptopurineNT5C2 protein, humanThioguanine

Identifiers

PMID30201983
OpenAlexW2890685869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.