Evidence map›Paper›PMID 30201883›Full record

ArticleNutrients2018

Brain Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet.

Lorena Gimenez da Silva-Santi, Marina Masetto Antunes, Marco Aurélio Mori, Camila Biesdorf de Almeida-Souza, Jesuí Vergílio Visentainer, Fabiana Carbonera, Amanda Rabello Crisma, Laureane Nunes Masi, Sandro Massao Hirabara, Rui Curi and 1 more

Abstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Effect ofBiomolecules · 2025
    Article
  5. Article
  6. Article
  7. Linseed oil attenuates fatty liver disease in mice fed a high-carbohydrate diet.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Monounsaturated Fatty Acids in Obesity-Related Inflammation.International journal of molecular sciences · 2020
    Review
  14. Review
  15. A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
    Article
  16. The Novel Perspectives of Adipokines on Brain Health.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lorena Gimenez da Silva-SantiDepartment of Pharmacology and Therapeutics, State University of Maringá, Maringá 87020-900, Paraná, Brazil. lorenajufem@gmail.com.
Marina Masetto AntunesDepartment of Pharmacology and Therapeutics, State University of Maringá, Maringá 87020-900, Paraná, Brazil. marinaantunes_1992@hotmail.com.
Marco Aurélio MoriDepartment of Pharmacology and Therapeutics, State University of Maringá, Maringá 87020-900, Paraná, Brazil. marcoaureliomori@gmail.com.ORCID 0000-0003-1231-8756
Camila Biesdorf de Almeida-SouzaDepartment of Pharmacology and Therapeutics, State University of Maringá, Maringá 87020-900, Paraná, Brazil. camila.biesdorf1@gmail.com.
Jesuí Vergílio VisentainerDepartment of Chemistry, State University of Maringá, Maringá 87020-900, Paraná, Brazil. jesuiv@gmail.com.
Fabiana CarboneraDepartment of Chemistry, State University of Maringá, Maringá 87020-900, Paraná, Brazil. fabianacarbonera@gmail.com.
Amanda Rabello CrismaDepartment of Clinical Analysis, Federal University of Paraná, Curitiba 80210-170, Paraná, Brazil. amycrisma@yahoo.com.br.
Laureane Nunes MasiInterdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo 03342-000, Brazil. laure_masi@hotmail.com.
Sandro Massao HirabaraInterdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo 03342-000, Brazil. sandromh@yahoo.com.br.
Rui CuriInterdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo 03342-000, Brazil. curirui@gmail.com.
Roberto Barbosa BazotteDepartment of Pharmacology and Therapeutics, State University of Maringá, Maringá 87020-900, Paraná, Brazil. rbbazotte@gmail.com.ORCID 0000-0001-8563-7913

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both high fat diet (HFD) and high carbohydrate diet (HCD) modulate brain fatty acids (FA) composition. Notwithstanding, there is a lack of information on time sequence of brain FA deposition either for HFD or HCD. The changes in brain FA composition in mice fed with HFD or HCD for 7, 14, 28, or 56 days were compared with results of 0 (before starting given the diets). mRNA expressions of allograft inflammatory factor 1 (Aif1), cyclooxygenase-2 (Cox 2), F4/80, inducible nitric oxide synthase (iNOS), integrin subunit alpha m (Itgam), interleukin IL-1β (IL-1β), IL-6, IL-10, and tumor necrosis factor alpha (TNF-α) were measured. The HFD group had higher speed of deposition of saturated FA (SFA), monounsaturated FA (MUFA), and polyunsaturated FA (PUFA) at the beginning of the experimental period. However, on day 56, the total amount of SFA, MUFA, and PUFA were similar. mRNA expressions of F4/80 and Itgam, markers of microglia infiltration, were increased (

Indexed as

AnimalsAntigens, DifferentiationBrainCalcium-Binding ProteinsCD11b AntigenCyclooxygenase 2CytokinesDietary CarbohydratesDietary FatsDiet, Carbohydrate LoadingDiet, High-FatFatty AcidsInflammationIntegrin alpha ChainsMaleMiceAif1 protein, mouseAntigens, DifferentiationCalcium-Binding ProteinsCD11b AntigenCyclooxygenase 2CytokinesDietary CarbohydratesDietary FatsFatty AcidsIntegrin alpha ChainsMicrofilament Proteinsmonocyte-macrophage differentiation antigenNitric Oxide SynthasePtgs2 protein, mouseRNA, Messengercytokinesmonounsaturated fatty acidsn-6/n-3 fatty acid rationutrientspolyunsaturated fatty acidssaturated fatty acids

Identifiers

PMID30201883
PMCPMC6164611

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.