Evidence map›Paper›PMID 30201845›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2018

OpenWorm: overview and recent advances in integrative biological simulation of

Gopal P Sarma, Chee Wai Lee, Tom Portegys, Vahid Ghayoomie, Travis Jacobs, Bradly Alicea, Matteo Cantarelli, Michael Currie, Richard C Gerkin, Shane Gingell and 9 more

Abstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Reductionism in Engram Neuroscience.The European journal of neuroscience · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. On collective behavior inFrontiers in neurorobotics · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Multisensory Integration inBrain sciences · 2022
    Review
  11. Article
  12. Computational Inference of Synaptic Polarities in Neuronal Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  13. Article
  14. Design Principles for Neurorobotics.Frontiers in neurorobotics · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Gopal P SarmaSchool of Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-9413-6202
Chee Wai LeeThe OpenWorm Foundation, New York, NY, USA.
Tom PortegysErnst and Young LLP, New York, NY, USA.
Vahid GhayoomieLaboratory of Systems Biology and Bioinformatics, University of Tehran, Tehran, Iran.
Travis JacobsMelonport AG, Zug, Switzerland.
Bradly AliceaOrthogonal Research, Champaign, IL, USA.ORCID 0000-0003-3869-3175
Matteo CantarelliThe OpenWorm Foundation, New York, NY, USA.
Michael CurrieFling Inc., Bangkok, Thailand.
Richard C GerkinSchool of Life Sciences, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-2940-3378
Shane GingellOut of the BOTS, Inc., Queensland, Australia.
Padraig GleesonDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID 0000-0001-5963-8576
Richard GordonEmbryogenesis Center, Gulf Specimen Marine Laboratory, Panacea, FL, USA.
Ramin M HasaniCyber-Physical Systems, Technische Universität Wien, Wien, Austria.
Giovanni IdiliThe OpenWorm Foundation, New York, NY, USA.
Sergey KhayrulinThe OpenWorm Foundation, New York, NY, USA.
David LungCyber-Physical Systems, Technische Universität Wien, Wien, Austria.
Andrey PalyanovLaboratory of Complex Systems Simulation, A.P. Ershov Institute of Informatics Systems, Novosibirsk, Russia.ORCID 0000-0003-1108-1486
Mark WattsRaytheon Company, Waltham, MA, USA.ORCID 0000-0002-6782-8510
Stephen D LarsonThe OpenWorm Foundation, New York, NY, USA stephen@openworm.org.ORCID 0000-0001-5397-6208

Funding

Tools for Model Discovery, Validation and Selection in Neuroscience with NeuroMLR01MH106674 · NIMH · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI CROOK, SHARON MARIE · 2015 to 2018
$1.6M
CRCNS Data Sharing: Exchange and Evaluation of Reduced Neuron ModlesR01EB021711 · NIBIB · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI GERKIN, RICHARD C · 2015 to 2017
$390k
NIBIB NIH HHS R01 EB021711NIMH NIH HHS R01 MH106674Wellcome Trust 101445
6 · The paper itself

Abstract

The adoption of powerful software tools and computational methods from the software industry by the scientific research community has resulted in a renewed interest in integrative, large-scale biological simulations. These typically involve the development of computational platforms to combine diverse, process-specific models into a coherent whole. The OpenWorm Foundation is an independent research organization working towards an integrative simulation of the nematode

Indexed as

Models, BiologicalAnimalsCaenorhabditis elegansConnectomebioinformaticsbiological simulationCaenorhabditis eleganscomputational neurosciencecomputational physiologysoftware engineering

Identifiers

PMID30201845
PMCPMC6158220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.