Evidence map›Paper›PMID 30201817›Full record

ArticleAntimicrobial agents and chemotherapy2018

Characterization of Influenza B Virus Variants with Reduced Neuraminidase Inhibitor Susceptibility.

R Farrukee, A E Zarebski, J M McCaw, J D Bloom, P C Reading, A C Hurt

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

R FarrukeeWHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
A E ZarebskiSchool of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia.
J M McCawSchool of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia.
J D BloomDivision of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
P C ReadingWHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
A C HurtWHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia aeron.hurt@influenzacentre.org.
University of Melbourne · AUPeter Doherty Institute · AUFred Hutch Cancer Center · US

Funding

High-throughput experiments to guide influenza vaccine strain selectionR01AI127893 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BLOOM, JESSE D · 2016 to 2020
$2.1M
FHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600k
NIAID NIH HHS R01 AI127893NIH HHS S10 OD020069
6 · The paper itself

Abstract

Treatment options for influenza B virus infections are limited to neuraminidase inhibitors (NAIs), which block the neuraminidase (NA) glycoprotein on the virion surface. The development of NAI resistance would therefore result in a loss of antiviral treatment options for influenza B virus infections. This study characterized two contemporary influenza B viruses with known resistance-conferring NA amino acid substitutions, D197N and H273Y, detected during routine surveillance. The D197N and H273Y variants were characterized

Indexed as

Amino Acid SubstitutionAnimalsAntiviral AgentsCell LineDogsDrug Resistance, ViralEnzyme InhibitorsFemaleFerretsHEK293 CellsHumansInfluenza B virusInfluenza, HumanMadin Darby Canine Kidney CellsMaleNeuraminidaseAntiviral AgentsEnzyme InhibitorsNeuraminidaseinfluenza Bneuraminidase inhibitorresistanceviral fitness

Identifiers

PMID30201817
PMCPMC6201084
OpenAlexW2950049957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.