Evidence map›Paper›PMID 30201814›Full record

ArticleAntimicrobial agents and chemotherapy2018

Isavuconazole for Treatment of Experimental Fungal Endophthalmitis Caused by Aspergillus fumigatus.

John M Guest, Pawan Kumar Singh, Sanjay G Revankar, Pranatharthi H Chandrasekar, Ashok Kumar

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 29 citations in OpenAlex.

  1. [Colonisation or early invasion? Disseminated aspergillosis after bronchial isolation ofRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Article
  2. Article
  3. Article
  4. Efficacy of Rezafungin onPathogens & immunity · 2025
    Article
  5. Article
  6. Electroretinographic Evaluations of Eyes With Endophthalmitis.Translational vision science & technology · 2024
    Article
  7. Article
  8. Article
  9. Eye fungal infections: a mini review.Archives of microbiology · 2023
    Review
  10. Article
  11. Journal of fungi (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Rapid Detection ofFrontiers in cellular and infection microbiology · 2021
    Article
  16. Review
  17. Isavuconazole-Animal Data and Clinical Data.Journal of fungi (Basel, Switzerland) · 2020
    Review
  18. Microglial Response toJournal of fungi (Basel, Switzerland) · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

John M Guest *Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, Michigan, USA.
Pawan Kumar Singh *Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, Michigan, USA.
Sanjay G RevankarDivision of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.
Pranatharthi H ChandrasekarDivision of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.
Ashok KumarDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, Michigan, USA akuma@med.wayne.edu.
Wayne State University · US

Funding

VISION RESEARCH--COREP30EY004068 · NEI · WAYNE STATE UNIVERSITY · PI LINDA D HAZLETT · 1985 to 2026
$13.2M
Targeting NAD metabolism to ameliorate bacterial endophthalmitisR01EY026964 · NEI · WAYNE STATE UNIVERSITY · PI Ashok Kumar · 2017 to 2026
$3.7M
NEI NIH HHS P30 EY004068NEI NIH HHS R01 EY026964
6 · The paper itself

Abstract

Fungal endophthalmitis remains a significant cause of vision impairment and blindness. Moreover, the prognosis is poor, in part due to delay in diagnosis and to limited availability of effective antifungal agents with good ocular penetration. Thus, it is imperative to evaluate the therapeutic efficacy in fungal endophthalmitis of newer antifungal agents. In this study, we assessed the efficacy of isavuconazole in treating

Indexed as

AnimalsAntifungal AgentsAspergillosisAspergillus fumigatusDisease Models, AnimalElectroretinographyEndophthalmitisEye Infections, FungalIntravitreal InjectionsMiceMice, Inbred C57BLNitrilesPyridinesRetinaTriazolesVitreous BodyAntifungal AgentsisavuconazoleNitrilesPyridinesTriazolesAspergillusendophthalmitisERGinflammationisavuconazoleocular immunologyretina

Identifiers

PMID30201814
PMCPMC6201095
OpenAlexW2891097012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.