Evidence map›Paper›PMID 30201775›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Suppressing Interferon-γ Stimulates Microglial Responses and Repair of Microbleeds in the Diabetic Brain.

Stephanie Taylor, Eslam Mehina, Emily White, Patrick Reeson, Kevin Yongblah, Kristian P Doyle, Craig E Brown

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. ECgo: All-optical induction of single endothelial cell injury and capillary occlusion in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  2. Review
  3. Review
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  7. Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. The importance of laminin at the blood-brain barrier.Neural regeneration research · 2023
    Review
  10. Article
  11. Sex and interferon gamma signaling regulate microglia migration in the adult mouse cortex in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Microglia and Microglia-Like Cells: Similar but Different.Frontiers in cellular neuroscience · 2022
    Review
  17. Review
  18. Review
  19. Article
  20. Role of interferons in diabetic retinopathy.World journal of diabetes · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Stephanie TaylorDivision of Medical Sciences, University of Victoria, Victoria, British Columbia V8P 5C2, Canada.
Eslam MehinaDivision of Medical Sciences, University of Victoria, Victoria, British Columbia V8P 5C2, Canada.
Emily WhiteDivision of Medical Sciences, University of Victoria, Victoria, British Columbia V8P 5C2, Canada.
Patrick ReesonDivision of Medical Sciences, University of Victoria, Victoria, British Columbia V8P 5C2, Canada.
Kevin YongblahDivision of Medical Sciences, University of Victoria, Victoria, British Columbia V8P 5C2, Canada.
Kristian P DoyleDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, Arizona 85724, and.
Craig E BrownDivision of Medical Sciences, University of Victoria, Victoria, British Columbia V8P 5C2, Canada, brownc@uvic.ca.
University of Victoria · CAUniversity of Arizona · USUniversity of British Columbia · CA

Funding

CIHR
6 · The paper itself

Abstract

Microcirculatory damage is a common complication for those with vascular risk factors, such as diabetes. To resolve vascular insults, the brain's immune cells (microglia) must rapidly envelop the site of injury. Currently, it is unknown whether Type 1 diabetes, a condition associated with chronic immune system dysfunction, alters microglial responses to damage and what mechanisms are responsible. Using

Indexed as

AnimalsCerebral CortexCerebral HemorrhageDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Disease Models, AnimalEncephalitisInterferon-gammaMaleMice, Inbred C57BLMicrogliaOptical ImagingIFNG protein, mouseInterferon-gammadiabetesinflammationinterferonmicrobleedsmicrogliarepair

Identifiers

PMID30201775
PMCPMC6596226
OpenAlexW2892381183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.