ArticleProceedings of the National Academy of Sciences of the United States of America2018
The brain's hemodynamic response function rapidly changes under acute psychosocial stress in association with genetic and endocrine stress response markers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 61 citations in OpenAlex.
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- BOLD Response is more than just magnitude: Improving detection sensitivity through capturing hemodynamic profiles.NeuroImage · 2023Article
- Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition.Neuroinformatics · 2023Article
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- Improving the validity of neuroimaging decoding tests of invariant and configural neural representation.PLoS computational biology · 2023Article
- The confound of hemodynamic response function variability in human resting-state functional MRI studies.Frontiers in neuroscience · 2023Article
- Temporal stability of the hemodynamic response function across the majority of human cerebral cortex.Human brain mapping · 2022Article
- Neurovascular coupling: motive unknown.Trends in neurosciences · 2022Review
- Reconstruction of time-shifted hemodynamic response.Scientific reports · 2022Article
- Computing hemodynamic response functions from concurrent spectral fiber-photometry and fMRI data.Neurophotonics · 2022Article
- Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes.Frontiers in physiology · 2022Article
- Anomalous and heterogeneous characteristics of the BOLD hemodynamic response function in white matter.Cerebral cortex communications · 2022Article
- Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation.Translational psychiatry · 2021Article
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10 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ample evidence links dysregulation of the stress response to the risk for psychiatric disorders. However, we lack an integrated understanding of mechanisms that are adaptive during the acute stress response but potentially pathogenic when dysregulated. One mechanistic link emerging from rodent studies is the interaction between stress effectors and neurovascular coupling, a process that adjusts cerebral blood flow according to local metabolic demands. Here, using task-related fMRI, we show that acute psychosocial stress rapidly impacts the peak latency of the hemodynamic response function (HRF-PL) in temporal, insular, and prefrontal regions in two independent cohorts of healthy humans. These latency effects occurred in the absence of amplitude effects and were moderated by regulatory genetic variants of
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