Evidence map›Paper›PMID 30201687›Full record

ArticleDevelopment (Cambridge, England)2018

A non-canonical role for the proneural gene

Sisu Han, Daniel J Dennis, Anjali Balakrishnan, Rajiv Dixit, Olivier Britz, Dawn Zinyk, Yacine Touahri, Thomas Olender, Marjorie Brand, François Guillemot and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
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  15. Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Chromatin Remodeling in the Brain-aInternational journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Sisu HanBiological Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Daniel J DennisBiological Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Anjali BalakrishnanBiological Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Rajiv DixitBiological Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Olivier BritzThe Francis Crick Institute-Mill Hill Laboratory, London NW7 1AA, UK.
Dawn ZinykBiological Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Yacine TouahriBiological Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Thomas OlenderOttawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.
Marjorie BrandOttawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.
François GuillemotThe Francis Crick Institute-Mill Hill Laboratory, London NW7 1AA, UK.
Deborah KurraschDepartment of Molecular Genetics, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
Carol SchuurmansBiological Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada cschuurm@sri.utoronto.ca.ORCID 0000-0002-3952-3031
Sunnybrook Health Science Centre · CAOttawa Hospital · CAThe Francis Crick Institute · GBUniversity of Calgary · CA

Funding

Cancer Research UK FC001089Medical Research Council FC001089Wellcome Trust FC001089
6 · The paper itself

Abstract

Neural progenitors undergo temporal identity transitions to sequentially generate the neuronal and glial cells that make up the mature brain. Proneural genes have well-characterised roles in promoting neural cell differentiation and subtype specification, but they also regulate the timing of identity transitions through poorly understood mechanisms. Here, we investigated how the highly related proneural genes

Indexed as

NeurogenesisAnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationCell ProliferationCell Self RenewalEmbryo, MammalianGene Expression Regulation, DevelopmentalMice, TransgenicNeocortexNerve Tissue ProteinsNeural Stem CellsNeurogliaNeuronsProtein BindingTime FactorsBasic Helix-Loop-Helix ProteinsNerve Tissue ProteinsNeurog1 protein, mouseNeurog2 protein, mousebHLH transcription factorsNeocortexNeurogenesisNeurogeninsProneural genes

Identifiers

PMID30201687
PMCPMC6198467
OpenAlexW2890693517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.