Evidence map›Paper›PMID 30201529›Full record

ArticleBiologicals : journal of the International Association of Biological Standardization2018

Establishment of the first International Standard for human anti-typhoid capsular Vi polysaccharide IgG.

Sjoerd Rijpkema, Jason Hockley, Alastair Logan, Peter Rigsby, Eleanor Atkinson, Celina Jin, David Goldblatt, Haoyu Liang, Novilia S Bachtiar, Jae Seung Yang and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Biologicals : journal of the International Association of Biological Standardization, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Multivalent vaccines for invasiveInfection and immunity · 2026
    Review
  5. Article
  6. Article
  7. Longevity of immune response after a single dose of typhoid conjugate vaccine against Salmonella Typhi among children in Hyderabad, Pakistan.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Glycoconjugate vaccines againstBiophysical reviews · 2021
    Review
  15. Article
  16. Evaluation of a standardised Vi poly-l-lysine ELISA for serology of Vi capsular polysaccharide antibodies.Biologicals : journal of the International Association of Biological Standardization · 2020
    Article
  17. Article
  18. Consensus Report on Shigella Controlled Human Infection Model: Immunological Assays.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 6 countries.

Sjoerd RijpkemaDivision of Bacteriology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, EN6 3QG, United Kingdom. Electronic address: Sjoerd.Rijpkema@nibsc.org.
Jason HockleyBiostatistics Group, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, EN6 3QG, United Kingdom.
Alastair LoganDivision of Bacteriology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, EN6 3QG, United Kingdom.
Peter RigsbyBiostatistics Group, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, EN6 3QG, United Kingdom.
Eleanor AtkinsonBiostatistics Group, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, EN6 3QG, United Kingdom.
Celina JinOxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
David GoldblattUniversity College London, Great Ormond Street Institute of Child Health, London, United Kingdom.
Haoyu LiangInstitute for Biological Product Control, National Institute for Food and Drug Control, No.2 Tiantan Xili, Beijing, People's Republic of China.
Novilia S BachtiarClinical Trial Department, Surveillance & Clinical Trial Division, Bio Farma, Jl.Pasteur No.28, Bandung, Indonesia.
Jae Seung YangClinical Immunology, International Vaccine Institute, SNU Research Park, 1 Kwanak-Ro, Kwanak-Gu, Seoul, Republic of Korea.
Akshay GoelR&D, Biological E. Ltd, MN Park, Genome Valley, Shameerpet, Hyderabad, 500078, Telangana, India.
Venkatesan RamasamyQuality Operations, Bharat Biotech International Ltd, Genome Valley, Shameerpet, Hyderabad, 500078, Telangana, India.
Marcela F PasettiCenter for Vaccine Development, University of Maryland Baltimore, 685 West Baltimore Street, Room 480, Baltimore, MD, USA.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
anti-Vi IgG working group
National Institute for Biological Standards and Control · GBBharat Biotech (India) · INBiological E (India) · INInternational Vaccine Institute · KRNational Institutes for Food and Drug Control · CNOxford BioMedica (United Kingdom) · GBPT Bio Farma (Indonesia) · IDUniversity College London · GBUniversity of Maryland, Baltimore · USUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vi capsular polysaccharide (Vi) conjugate vaccines, which can prevent typhoid in infants and young children, are being developed. Comparative immunogenicity studies are facilitated by an International Standard (IS) for human anti-Vi IgG. 16/138, a pool of sera from volunteers which received either Vi conjugate vaccine or plain Vi vaccine, was assessed as an IS alongside U.S. reference reagent Vi-IgG

Indexed as

Immunogenicity, VaccineAdolescentAdultAntibodies, BacterialEnzyme-Linked Immunosorbent AssayHealthy VolunteersHumansImmunoglobulin GMiddle AgedPolysaccharides, BacterialReference StandardsSalmonella typhiTyphoid FeverTyphoid-Paratyphoid VaccinesVaccines, ConjugateYoung AdultAntibodies, BacterialImmunoglobulin GPolysaccharides, BacterialTyphoid-Paratyphoid VaccinesVaccines, ConjugateVi polysaccharide vaccine, typhoidELISAIgGInternational standardPolysaccharideTyphoidVi

Identifiers

PMID30201529
PMCPMC6238147
OpenAlexW2810103791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.