SynthesisThe Journal of allergy and clinical immunology2019
An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos.
Abstract readMeta-Analysis
In one paragraph
Synthesis in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
What it found
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The trial behind it
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Genetic ancestry is associated with asthma, and this could be modified by environmental factors. A systematic review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Pooled it
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Integrated drivers of basal and acute immunity in diverse human populations.Cell reports. Medicine · 2026Article
- Precision Medicine: Personalizing Healthcare by Bridging Aging, Genetics, and Global Diversity.Healthcare (Basel, Switzerland) · 2025Review
- Psychiatric genetics in the diverse landscape of Latin American populations.Nature genetics · 2025Review
- Opportunities and challenges of local ancestry in genetic association analyses.American journal of human genetics · 2025Review
- Fast and accurate local ancestry inference with Recomb-Mix.bioRxiv : the preprint server for biology · 2024Article
- El Hierro Genome Study: A Genomic and Health Study in an Isolated Canary Island Population.Journal of personalized medicine · 2024Article
- Principles and methods for transferring polygenic risk scores across global populations.Nature reviews. Genetics · 2024Review
- 5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function.Frontiers in allergy · 2024Article
- Strategies for the Genomic Analysis of Admixed Populations.Annual review of biomedical data science · 2023Review
- Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth.Thorax · 2023Article
- Leveraging genetic ancestry to study severe asthma exacerbations in an admixed population.Thorax · 2023Article
- Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.Clinical and translational allergy · 2023Review
- Asthma in the Americas: An Update: A Joint Perspective from the Brazilian Thoracic Society, Canadian Thoracic Society, Latin American Thoracic Society, and American Thoracic Society.Annals of the American Thoracic Society · 2022Review
- Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm.Journal of personalized medicine · 2022Review
- Targeted analysis of genomic regions enriched in African ancestry reveals novel classical HLA alleles associated with asthma in Southwestern Europeans.Scientific reports · 2021Article
- Admixture mapping analysis reveals differential genetic ancestry associated with Chagas disease susceptibility in the Colombian population.Human molecular genetics · 2021Article
- Characterizing the Genetic Architecture of Parkinson's Disease in Latinos.Annals of neurology · 2021Article
- Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
53 authors at 20 institutions in 5 countries.
Christopher R GignouxProgram in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, Calif; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, Calif. Electronic address: chris.gignoux@ucdenver.edu.
Dara G TorgersonDepartment of Medicine, University of California, San Francisco, San Francisco, Calif.
Maria Pino-YanesDepartment of Medicine, University of California, San Francisco, San Francisco, Calif; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Lawrence H UricchioDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, Calif.
Joshua GalanterDepartment of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, Calif; Department of Medicine, University of California, San Francisco, San Francisco, Calif.
Lindsey A RothDepartment of Medicine, University of California, San Francisco, San Francisco, Calif.
Celeste EngDepartment of Medicine, University of California, San Francisco, San Francisco, Calif.
Donglei HuDepartment of Medicine, University of California, San Francisco, San Francisco, Calif.
Elizabeth A NguyenDepartment of Medicine, University of California, San Francisco, San Francisco, Calif.
Scott HuntsmanDepartment of Medicine, University of California, San Francisco, San Francisco, Calif.
Rasika A MathiasDepartment of Medicine, Johns Hopkins University, Baltimore, Md.
Rajesh KumarAnn and Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Jose Rodriguez-SantanaCentro de Neumologia Pediatrica, San Juan, Puerto Rico.
Neeta ThakurDepartment of Medicine, University of California, San Francisco, San Francisco, Calif.
Sam S OhDepartment of Medicine, University of California, San Francisco, San Francisco, Calif.
Meghan McGarryDepartment of Pediatrics, University of California, San Francisco, San Francisco, Calif.
Andres Moreno-EstradaDepartment of Genetics, Stanford University, Palo Alto, Calif.
Karla SandovalDepartment of Genetics, Stanford University, Palo Alto, Calif.
Cheryl A WinklerMolecular Genetics Epidemiology Section, Frederick National Laboratory for Cancer Research, Frederick, Md.
Max A SeiboldIntegrated Center for Genes, Environment, and Health, Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo.
Badri PadhukasahasramCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Mich.
David V ContiDepartment of Preventative Medicine, University of Southern California, Los Angeles, Calif.
Harold J FarberDepartment of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex.
Pedro AvilaDivision of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Emerita Brigino-BuenaventuraDepartment of Allergy & Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, Calif.
Michael LenoirBay Area Pediatrics, Oakland, Calif.
Kelley MeadeChildren's Hospital and Research Center Oakland, Oakland, Calif.
Denise SerebriskyPediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY.
Luisa N BorrellDepartment of Health Sciences, Graduate Program in Public Health, Lehman College, City University of New York, Bronx, NY.
William Rodriguez-CintronVeterans Caribbean Health Care System, San Juan, Puerto Rico.
Shannon ThyneDepartment of Medicine, University of California, San Francisco, San Francisco, Calif.
Bonnie R JoubertNational Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Isabelle RomieuNutritional Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Albert M LevinCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Mich.
Juan-Jose Sienra-MongeDepartmento de Alergia e Inmunologia, Clinica Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico.
Blanca Estela Del Rio-NavarroDepartmento de Alergia e Inmunologia, Clinica Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico.
Weiniu GanDivision of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Md.
Benjamin A RabyDepartment of Medicine, Harvard Medical School, Boston, Mass.
Scott T WeissDepartment of Medicine, Harvard Medical School, Boston, Mass.
Eugene BleeckerCenter for Genomics & Personalized Medicine Research, Wake Forest University, Winston-Salem, NC.
Deborah A MeyersCenter for Genomics & Personalized Medicine Research, Wake Forest University, Winston-Salem, NC.
Fernando J MartinezBIO5 Institute, University of Arizona, Tucson, Ariz.
W James GaudermanDepartment of Preventative Medicine, University of Southern California, Los Angeles, Calif.
Frank GillilandDepartment of Preventative Medicine, University of Southern California, Los Angeles, Calif.
Stephanie J LondonNational Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Carlos D BustamanteDepartment of Genetics, Stanford University, Palo Alto, Calif.
Dan L NicolaePhysical Sciences Division, Department of Statistics, University of Chicago, Chicago, Ill.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, Ill.
Saunak SenDepartment of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, Tenn.
Kathleen BarnesDepartment of Medicine, Johns Hopkins University, Baltimore, Md.
L Keoki WilliamsCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Mich; Department of Internal Medicine, Henry Ford Health System, Detroit, Mich.
Ryan D HernandezProgram in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, Calif; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, Calif.
Esteban G BurchardProgram in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, Calif; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, Calif; Department of Medicine, University of California, San Francisco, San Francisco, Calif.
University of California, San Francisco · USHenry Ford Health System · USStanford University · USUniversity of Southern California · USHarvard University · USHospital Infantil de México Federico Gómez · MXJohns Hopkins University · USUniversity of Chicago · USWake Forest University · USCentre International de Recherche sur le Cancer · FRCentro de Neumologia Pediatrica · PRFrederick National Laboratory for Cancer Research · USJacobi Medical Center · USKaiser Permanente Vallejo Medical Center · USKIPP Bay Area Schools · USLehman College · USLurie Children's Hospital · USNational Heart Lung and Blood Institute · USNational Institute of Environmental Health Sciences · USNational Institutes of Health · US
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle · 2008 to 2026
$41.1MINSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MZOLENDRONIC ACID IN CHILDREN W/ SEVERE OSTEOGENESIS IMPERFECTAM01RR000188 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI PLON, SHARON E. · 1985 to 2011
$30.6MNew Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1MSystems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6MClinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9MGenetics of Renal Disease in African AmericansZIABC010022 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINKLER, CHERYL · 2009 to 2022
$8.9MThe EVE Asthma Genetics Consortium: Building Upon GWASRC2HL101651 · NHLBI · UNIVERSITY OF CHICAGO · PI NICOLAE, DAN LIVIU, OBER, CAROLE · 2009 to 2010
$7.4MPHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1MGenetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8MBMI Bioinformatics Training GrantsT32GM067547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, RYAN D. · 2003 to 2022
$6.6MSocial Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4MARRA NIH HHSNCATS NIH HHS KL2 TR000143NCI NIH HHS HHSN261200800001ENCI NIH HHS R25 CA113710NCI NIH HHS T32 CA113710NCRR NIH HHS M01 RR000188NHGRI NIH HHS K22 HG000044NHGRI NIH HHS T32 HG000044NHLBI NIH HHS K23 HL111636NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL078885NHLBI NIH HHS R01 HL079055NHLBI NIH HHS R01 HL087699NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL118267NHLBI NIH HHS RC2 HL101651NIAID NIH HHS R01 AI061774NIAID NIH HHS R01 AI079139NIAID NIH HHS U19 AI077439NIDDK NIH HHS R01 DK064695NIDDK NIH HHS R01 DK113003NIEHS NIH HHS R01 ES015794NIGMS NIH HHS T32 GM007175NIMHD NIH HHS P60 MD006902World Health Organization 001
Abstract
backgroundAsthma is a common but complex disease with racial/ethnic differences in prevalence, morbidity, and response to therapies.
objectiveWe sought to perform an analysis of genetic ancestry to identify new loci that contribute to asthma susceptibility.
methodsWe leveraged the mixed ancestry of 3902 Latinos and performed an admixture mapping meta-analysis for asthma susceptibility. We replicated associations in an independent study of 3774 Latinos, performed targeted sequencing for fine mapping, and tested for disease correlations with gene expression in the whole blood of more than 500 subjects from 3 racial/ethnic groups.
resultsWe identified a genome-wide significant admixture mapping peak at 18q21 in Latinos (P = 6.8 × 10
conclusionAncestry at 18q21 was significantly associated with asthma in Latinos and implicated multiple ancestry-informative noncoding variants upstream of SMAD2 with asthma susceptibility. Furthermore, decreased SMAD2 expression in blood was strongly associated with increased asthma risk and increased exacerbations.
Indexed as
Chromosomes, Human, Pair 18Genetic Predisposition to DiseaseAsthmaChromosome MappingHispanic or LatinoHumansPolymorphism, Single NucleotideSmad2 ProteinSmad2 ProteinSMAD2 protein, humanadmixture mappingAsthmaasthma exacerbationsgene expressionLatinosmeta-analysisrare variationSMAD2targeted sequencing
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