ArticleNeuroImage2019
The effects of breastfeeding versus formula-feeding on cerebral cortex maturation in infant rhesus macaques.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Association between the Infant and Child Feeding Index at 8 months and early childhood neurodevelopment.Frontiers in nutrition · 2025Article
- Article
- Gestational and early postnatal protein malnutrition disrupts neurodevelopment in rhesus macaques.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Human Breast Organoid Models for Lactation Research.Reproduction and breeding · 2023Article
- Longitudinal mapping of the development of cortical thickness and surface area in rhesus macaques during the first three years.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Brain volumetrics across the lifespan of the rhesus macaque.Neurobiology of aging · 2023Article
- Review
- Carotenoids improve the development of cerebral cortical networks in formula-fed infant macaques.Scientific reports · 2022Article
- Decoding the Role of Gut-Microbiome in the Food Addiction Paradigm.International journal of environmental research and public health · 2021Review
- Structural development of cortical lobes during the first 6 months of life in infant macaques.Developmental cognitive neuroscience · 2021Article
- Nutri-Epigenetics and Gut Microbiota: How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced?International journal of molecular sciences · 2020Review
- In utero MRI identifies consequences of early-gestation alcohol drinking on fetal brain development in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Late weaning and maternal closeness, associated with advanced motor and visual maturation, reinforce autonomy in healthy, 2-year-old children.Scientific reports · 2020Article
- A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy.PloS one · 2020Article
- Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk.BMC nutrition · 2020Article
- Breastfeeding Duration Is Associated with Regional, but Not Global, Differences in White Matter Tracts.Brain sciences · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Breastfeeding is positively associated with several outcomes reflecting early brain development and cognitive functioning. Brain neuroimaging studies have shown that exclusively breastfed children have increased white matter and subcortical gray matter volume compared to formula-fed children. However, it is difficult to disentangle the effects of nutrition in breast milk from other confounding factors that affect brain development, particularly in studies of human subjects. Among the nutrients provided by human breast milk are the carotenoid lutein and the natural form of tocopherol, both of which are selectively deposited in brain. Lutein is the predominant carotenoid in breast milk but not in most infant formulas, whereas infant formulas are supplemented with the synthetic form of tocopherol. In this study, a non-human primate model was used to investigate the effects of breastfeeding versus formula-feeding, as well as lutein and natural RRR-α-tocopherol supplementation of infant formula, on brain maturation under controlled experimental conditions. Infant rhesus macaques (Macaca mulatta) were exclusively breastfed, or were fed infant formulas with different levels and sources of lutein and α-tocopherol. Of note, the breastfed group were mother-reared whereas the formula-fed infants were nursery-reared. Brain structural and diffusion MR images were collected, and brain T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.