ArticleNeurobiology of aging2018
Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.
Open access · greenAbstract read
In one paragraph
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Genome-wide epistasis analysis reveals significant epistatic signals associated with Parkinson's disease risk.Brain : a journal of neurology · 2025Article
- Complex genetic interactions affect susceptibility to Alzheimer's disease risk in the BIN1 and MS4A6A loci.GeroScience · 2025Article
- Navigating the blurred boundary: Neuropathologic changes versus clinical symptoms in Alzheimer's disease, and its consequences for research in genetics.Journal of Alzheimer's disease : JAD · 2025Review
- A crucial role of miR-155 in the pathomechanism of acute kidney injury.Frontiers in pharmacology · 2025Review
- The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer's disease.Open biology · 2024Article
- Identification of Tau Toxicity Modifiers in the Drosophila Eye.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Characterization of genomic regions escaping epigenetic reprogramming in sheep.Environmental epigenetics · 2024Article
- Leveraging the genetic correlation between traits improves the detection of epistasis in genome-wide association studies.G3 (Bethesda, Md.) · 2023Article
- Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease.Molecular psychiatry · 2023Review
- The Construction of a Multidomain Risk Model of Alzheimer's Disease and Related Dementias.Journal of Alzheimer's disease : JAD · 2023Article
- Genome-Wide Association Study of Parasite Resistance to Gastrointestinal Nematodes in Corriedale Sheep.Genes · 2022Article
- The Big Picture of Neurodegeneration: A Meta Study to Extract the Essential Evidence on Neurodegenerative Diseases in a Network-Based Approach.Frontiers in aging neuroscience · 2022Article
- Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine.Frontiers in aging neuroscience · 2022Review
- Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.Mechanisms of ageing and development · 2021Article
- The phenotypic and transcriptomic effects of developmental exposure to nanomolar levels of estrone and bisphenol A in zebrafish.The Science of the total environment · 2021Article
- Common Factors in Neurodegeneration: A Meta-Study Revealing Shared Patterns on a Multi-Omics Scale.Cells · 2020Article
- Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease.Neurobiology of aging · 2020Article
- Sex-dependent effect ofDisease models & mechanisms · 2020Review
- The multiplex model of the genetics of Alzheimer's disease.Nature neuroscience · 2020Review
- Association of childhood traumatization and neuropsychiatric outcomes with altered plasma micro RNA-levels.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 13 institutions in 5 countries.
Elena S GusarevaMedical Genomics Research Unit, GIGA-R, University of Liège, Belgium. Electronic address: gusareva.elena@gmail.com.
Jean-Claude TwizereMolecular Biology of Diseases Research Unit, GIGA-R, University of Liège, Belgium.
Kristel SleegersNeurodegenerative Brain Diseases group, Center for Molecular Neurology, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Pierre DourlenU1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissementa, Universite de Lille Nord de France, Lille, France; NSERM U1167, Institut Pasteur de Lille, Universite de Lille Nord de France, Lille, France.
Jose F AbisambraSanders-Brown Center on Aging, University of Kentucky, College of Medicine, Lexington, KY, USA; Department of Physiology, University of Kentucky, College of Medicine, Lexington, KY, USA; Epilepsy Center, University of Kentucky, College of Medicine, Lexington, KY, USA; Spinal Cord and Brain Injury Research Center, University of Kentucky, College of Medicine, Lexington, KY, USA.
Shelby MeierSanders-Brown Center on Aging, University of Kentucky, College of Medicine, Lexington, KY, USA; Department of Physiology, University of Kentucky, College of Medicine, Lexington, KY, USA.
Ryan CloydSanders-Brown Center on Aging, University of Kentucky, College of Medicine, Lexington, KY, USA.
Blaine WeissSanders-Brown Center on Aging, University of Kentucky, College of Medicine, Lexington, KY, USA.
Bart DermautU1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissementa, Universite de Lille Nord de France, Lille, France; NSERM U1167, Institut Pasteur de Lille, Universite de Lille Nord de France, Lille, France.
Kyrylo BessonovMedical Genomics Research Unit, GIGA-R, University of Liège, Belgium.
Sven J van der LeeDepartment of Epidemiology, Erasmus University Medical center, Rotterdam, the Netherlands.
Minerva M CarrasquilloDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.
Yuriko KatsumataDepartment of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA.
Majid CherkaouiMolecular Biology of Diseases Research Unit, GIGA-R, University of Liège, Belgium.
Bob AsselberghNeurodegenerative Brain Diseases group, Center for Molecular Neurology, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
M Arfan IkramDepartment of Neurology, Erasmus University Medical center, Rotterdam, the Netherlands; Department of Radiology, Erasmus University Medical center, Rotterdam, the Netherlands.
Richard MayeuxDepartment of Neurology, Gertrude H. Sergievsky Center, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Lindsay A FarrerDepartments of Biostatistics, Medicine (Genetics Program), Ophthalmology, Neurology, and Epidemiology, Boston University, Boston, MA, USA.
Jonathan L HainesDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
Margaret A Pericak-VanceDepartment of Human Genetics, The John P. Hussman Institute for Human Genomics, Dr John T. Macdonald Foundation, University of Miami, Coral Gables, FL, USA.
Gerard D SchellenbergDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Genetic and Environmental Risk in Alzheimer's Disease 1 consortium (GERAD1)
Alzheimer's Disease Genetics Consortium (ADGC)
European Alzheimer Disease Initiative Investigators (EADI1 Consortium)
Rebecca SimsMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
Julie WilliamsMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
Philippe AmouyelNSERM U1167, Institut Pasteur de Lille, Universite de Lille Nord de France, Lille, France.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical center, Rotterdam, the Netherlands.
Nilüfer Ertekin-TanerDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA.
Christine Van BroeckhovenNeurodegenerative Brain Diseases group, Center for Molecular Neurology, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Franck DequiedtMolecular Biology of Diseases Research Unit, GIGA-R, University of Liège, Belgium.
David W FardoDepartment of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
Jean-Charles LambertNSERM U1167, Institut Pasteur de Lille, Universite de Lille Nord de France, Lille, France.
Kristel Van SteenMedical Genomics Research Unit, GIGA-R, University of Liège, Belgium; Walloon Excellence in Life sciences and BIOtechnology (WELBIO), Belgium; Department of Human Genetics, KU Leuven, Leuven, Belgium.
University of Kentucky · USUniversity of Liège · BEUniversité de Lille · FRUniversity of Antwerp · BEErasmus MC · NLCardiff University · GBBoston University · USCase Western Reserve University · USColumbia University · USJacksonville College · USMayo Clinic in Florida · USUniversity of Miami · USUniversity of Pennsylvania · US
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MIntegrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, PETERS, METTE · 2013 to 2022
$24.6MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MGene discovery in PSP by transcriptome, neuropathology and sequence analysisR01NS080820 · NINDS · MAYO CLINIC JACKSONVILLE · PI ERTEKIN-TANER, NILUFER · 2013 to 2017
$1.8MPERK as a Central Mediator of Neurotoxicity in TauopathiesR01NS091329 · NINDS · UNIVERSITY OF KENTUCKY · PI ABISAMBRA, JOSE FRANCISCO · 2015 to 2019
$1.6MGenome wide association study of gene expression levels in Alzheimer's diseaseR01AG032990 · NIA · MAYO CLINIC JACKSONVILLE · PI ERTEKIN-TANER, NILUFER · 2009 to 2011
$932kMedical Research Council G0300429Medical Research Council G0600237Medical Research Council G0902227Medical Research Council MR/K013041/1Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Medical Research Council MR/L501517/1Medical Research Council MR/M009076/1NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG032990NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046139NIA NIH HHS U24 AG021886NIMHD NIH HHS L32 MD009205NINDS NIH HHS R01 NS080820NINDS NIH HHS R01 NS091329
Abstract
Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a hypothesis-free sex-stratified genome-wide screening for epistasis contributing to Alzheimer's disease (AD) susceptibility. We identified a statistical epistasis signal between the single nucleotide polymorphisms rs3733980 and rs7175766 that was associated with AD in males (genome-wide significant p
Indexed as
Sex CharacteristicsAlzheimer DiseaseCohort StudiesEpistasis, GeneticFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMeta-Analysis as TopicPhosphoproteinsSex FactorsTalinIntracellular Signaling Peptides and ProteinsPhosphoproteinsTalinTLN2 protein, humanWWC1 protein, humanAlzheimer's diseaseEpistasisGene-gene interactionProtein-protein interactionTLN2WWC1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.