Evidence map›Paper›PMID 30201267›Full record

ArticleJournal of molecular biology2018

Dynamic Interplay of RNA and Protein in the Human Immunodeficiency Virus-1 Reverse Transcription Initiation Complex.

Aaron T Coey, Kevin P Larsen, Junhong Choi, Daniel J Barrero, Joseph D Puglisi, Elisabetta Viani Puglisi

Abstract read
In one paragraph

Article in Journal of molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Extended Interactions between HIV-1 Viral RNA and tRNAInternational journal of molecular sciences · 2020
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Relating Structure and Dynamics in RNA Biology.Cold Spring Harbor perspectives in biology · 2019
    Review
  7. Intrinsic conformational dynamics of the HIV-1 genomic RNA 5'UTR.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  8. Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aaron T CoeyDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 943055126, USA; Biophysics Program Stanford University School of Medicine, Stanford, CA 94305-5126, USA.
Kevin P LarsenDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 943055126, USA; Biophysics Program Stanford University School of Medicine, Stanford, CA 94305-5126, USA.
Junhong ChoiDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 943055126, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305-5126, USA.
Daniel J BarreroDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 943055126, USA.
Joseph D PuglisiDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 943055126, USA.
Elisabetta Viani PuglisiDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 943055126, USA. Electronic address: epuglisi@stanford.edu.

Funding

X-ray Cryst. CoreP50GM082545 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2007 to 2018
$51.1M
Molecular Biophysics Training Program at StanfordT32GM008294 · NIGMS · STANFORD UNIVERSITY · PI HUANG, KERWYN C. · 1989 to 2019
$7.4M
NIGMS NIH HHS P50 GM082545NIGMS NIH HHS T32 GM008294
6 · The paper itself

Abstract

The initiation of reverse transcription in human immunodeficiency virus-1 is a key early step in the virus replication cycle. During this process, the viral enzyme reverse transcriptase (RT) copies the single-stranded viral RNA (vRNA) genome into double-stranded DNA using human tRNA

Indexed as

Binding SitesDNAFluorescence Resonance Energy TransferHIV-1HIV Reverse TranscriptaseModels, MolecularNucleic Acid ConformationReverse TranscriptionRNA StabilityRNA, TransferRNA, ViralSingle Molecule ImagingDNAHIV Reverse TranscriptaseRNA, TransferRNA, ViralHIV-1protein and RNA interactionsreverse transcriptaseRNA dynamicssingle-molecule FRET

Identifiers

PMID30201267
PMCPMC6289658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.