ReviewNeuroscience and biobehavioral reviews2018
Adolescence as a neurobiological critical period for the development of higher-order cognition.
Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 440 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
440 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- School-based psychosocial interventions for refugee and conflict-affected adolescents in Middle Eastern countries: a systematic review and meta-analysis.Journal of public health (Oxford, England) · 2026Pooled it
- Convergent blood-brain barrier breakdown in schizophrenia and autism spectrum disorders: a systematic review of preclinical animal models.Fluids and barriers of the CNS · 2026Pooled it
- Executive functioning in adolescents with internalizing disorders: a systematic review.European child & adolescent psychiatry · 2026Pooled it
- The Impact of Adverse Childhood Experiences on Cognitive Control Across the Lifespan: A Systematic Review and Meta-analysis of Prospective Studies.Trauma, violence & abuse · 2025Pooled it
- Physical activity and two-year change in adolescent well-being in nine countries.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025Pooled it
- Cognitive Remediation for Adolescents With Mental Health Disorders: A Systematic Review and Meta-Analysis.Early intervention in psychiatry · 2025Pooled it
- Early psychosocial deprivation alters the refinement of neural dynamics across adolescence.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- The role of reward-related brain activity in response to treatment and later depression severity: data from a randomized controlled trial in early adolescents with anxiety disorders.Translational psychiatry · 2025Trial
- What makes a lonely child: environmental, health, and multimodal neuroimaging correlates of prospective loneliness in the ABCD study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Sex and stress paradigm influence behavioural, neuroimmune, and microbiome responses in pubertal CD-1 mice.Brain, behavior, & immunity - health · 2026Article
- Adolescents' Perspectives on Self-Regulation and Need for Change in Digital Media Use: A Focus Group Study.Journal of adolescence · 2026Article
- Parent-Child Cortical Similarity Indexes Multiple Dimensions of Sensitivity in the Association Between Family Environment and Adolescent Internalizing Symptoms.bioRxiv : the preprint server for biology · 2026Article
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- Adolescent-Centered Cannabis Messaging in Clinical Settings: Preliminary Qualitative Insights From Adolescents for Clinicians.The Permanente journal · 2026Article
- The Adolescent Microbiome-Gut-Brain Axis: Development, Mechanisms, and Translational Perspectives.Nutrients · 2026Review
- The developing adolescent brain: Implications for youth justice and children in criminal proceedings.Developmental cognitive neuroscience · 2026Article
- The network and core dimensions of individual emotion regulation competency in late adolescence: A study based on longitudinal network analysis.The British journal of developmental psychology · 2026Article
- Impact of mobile health interventions for mental health literacy: A systematic review and meta-analysis of randomized controlled trials.PLOS digital health · 2026Article
- Same ages, different stages: Pubertal development in 9- and 10-year olds is associated with entropy of fMRI signals.Developmental cognitive neuroscience · 2026Article
- Long-term effects of adolescent risperidone treatment on the mouse cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
380 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The transition from adolescence to adulthood is characterized by improvements in higher-order cognitive abilities and corresponding refinements of the structure and function of the brain regions that support them. Whereas the neurobiological mechanisms that govern early development of sensory systems are well-understood, the mechanisms that drive developmental plasticity of association cortices, such as prefrontal cortex (PFC), during adolescence remain to be explained. In this review, we synthesize neurodevelopmental findings at the cellular, circuit, and systems levels in PFC and evaluate them through the lens of established critical period (CP) mechanisms that guide early sensory development. We find remarkable correspondence between these neurodevelopmental processes and the mechanisms driving CP plasticity, supporting the hypothesis that adolescent development is driven by CP mechanisms that guide the rapid development of neurobiology and cognitive ability during adolescence and their subsequent stability in adulthood. Critically, understanding adolescence as a CP not only provides a mechanism for normative adolescent development, it provides a framework for understanding the role of experience and neurobiology in the emergence of psychopathology that occurs during this developmental period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.