Evidence map›Paper›PMID 30201219›Full record

ReviewNeuroscience and biobehavioral reviews2018

The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation.

Larissa N Dooley, Kate R Kuhlman, Theodore F Robles, Naomi I Eisenberger, Michelle G Craske, Julienne E Bower

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  10. Opioidergic modulation of stress-induced hyperalgesia in adult zebrafish.Journal of neural transmission (Vienna, Austria : 1996) · 2026
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  12. Negative affect and peripheral inflammation: The role of cognitive reappraisal and expressive suppression.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Larissa N DooleySEE Change Institute, Los Angeles, CA 90291, USA.
Kate R KuhlmanDepartment of Psychological Science, University of California Irvine, Irvine, CA 92697, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: krkuhl@uci.edu.
Theodore F RoblesCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Naomi I EisenbergerCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Michelle G CraskeDepartment of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Julienne E BowerCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA.

Funding

Behavioral and inflammatory responses to stress: Implications for depression in youth exposed to adversityK08MH112773 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUHLMAN, KATE RYAN · 2017 to 2021
$862k
NIMH NIH HHS K08 MH112773
6 · The paper itself

Abstract

A wealth of evidence has implicated inflammation in the development of depression. Yet, the heterogeneous nature of depression has impeded efforts to understand, prevent, and treat the disease. The purpose of this integrative review is to summarize the connections between inflammation and established core features of depression that exhibit more homogeneity than the syndrome itself: exaggerated reactivity to negative information, altered reward processing, decreased cognitive control, and somatic syndrome. For each core feature, we first provide a brief overview of its relevance to depression and neurobiological underpinnings, and then review evidence investigating a potential role of inflammation. We focus primarily on findings from experimental paradigms of exogenously-induced inflammation. We conclude that inflammation likely plays a role in exaggerated reactivity to negative information, altered reward reactivity, and somatic symptoms. There is less evidence supporting an effect of inflammation on cognitive control as assessed by standard neuropsychological measures. Finally, we discuss implications for future research and recommendationsfor how to test the role of inflammation in the pathogenesis of heterogeneous psychiatric disorders.

Indexed as

AnimalsDepressionDepressive DisorderHumansInflammationCognitive controlDepressionEndophenotypeInflammationMoodRewardSomatic

Identifiers

PMID30201219
PMCPMC6192535

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.