Evidence map›Paper›PMID 30201100›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018

Helicobacter pylori seropositivity and its association with incident all-cause and Alzheimer's disease dementia in large national surveys.

May A Beydoun, Hind A Beydoun, Martine Elbejjani, Gregory A Dore, Alan B Zonderman

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Prevalence ofWorld journal of gastroenterology · 2024
    Pooled it
  3. Pooled it
  4. Article
  5. Review
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  9. Article
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  13. Brain communications · 2024
    Article
  14. Article
  15. Article
  16. Review of Phytochemical Potency as a Natural Anti-Molecules (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Cardiovascular health, infection burden, and incident dementia in the UK Biobank.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

May A BeydounLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD, USA. Electronic address: baydounm@mail.nih.gov.
Hind A BeydounDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Martine ElbejjaniLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD, USA.
Gregory A DoreLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD, USA.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD, USA.
National Institute on Aging · USJohns Hopkins Medicine · US

Funding

Health disparities in cognitive performance across the life spanZ01AG000194 · NIA · NATIONAL INSTITUTE ON AGING · PI ZONDERMAN, ALAN B · 2008 to 2008
$703k
Intramural NIH HHS Z01 AG000194
6 · The paper itself

Abstract

introductionInfectious agents were recently implicated in Alzheimer's disease (AD) and etiology of other dementias, notably Helicobacter pylori.

methodsWe tested associations of H. pylori seropositivity with incident all-cause and AD dementia and with AD-related mortality among US adults in a retrospective cohort study. Data from the National Health and Nutrition Surveys III, phase 1 (1988-1991) and 1999-2000 linked with Medicare and National Death Index registries, were used (baseline age ≥45 y, follow-up to 2013, N

resultsA positive association between H. pylori seropositivity and AD mortality was found in men (hazard ratio DISCUSSION: In sum, H. pylori seropositivity's direct association with AD mortality, all-cause dementia, and AD dementia was restricted to men and to higher socioeconomic status groups.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAntibodies, BacterialCross-Sectional StudiesFemaleHelicobacter InfectionsHelicobacter pyloriHumansIncidenceMaleMiddle AgedNutrition SurveysRetrospective StudiesSex FactorsSocioeconomic FactorsAntibodies, BacterialAgingAlzheimer's diseaseDementiaHelicobacter pyloriMortality

Identifiers

PMID30201100
PMCPMC6196325
OpenAlexW2809829664

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.