Evidence map›Paper›PMID 30201082›Full record

SynthesisBlood transfusion = Trasfusione del sangue2018

Efficacy of platelet-rich plasma as conservative treatment in orthopaedics: a systematic review and meta-analysis.

Massimo Franchini, Mario Cruciani, Carlo Mengoli, Giuseppe Marano, Simonetta Pupella, Eva Veropalumbo, Francesca Masiello, Ilaria Pati, Stefania Vaglio, Giancarlo M Liumbruno

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Blood transfusion = Trasfusione del sangue, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04571073 phase1completednot on this map

Manual Therapy Informed by the Fascia Distortion Model for Plantar Heel Pain: Results of a Single-arm Prospective Effectiveness Study

TypeinterventionalSponsorEisenhower Army Medical CenterRan2018 to 2019Enrolled33ConditionsPlantar Fasciitis of Both FeetArmsFascial Distortion Model
NCT05660824 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness of Stromal Vascular Fraction (SVF) and Platelet -Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study : (SPOST Study)

TypeinterventionalSponsorAdrien SchwitzguebelRan2025 to 2027Enrolled108ConditionsOsteoarthritisArmsStromal Vascular Fraction infiltration, Plattelet Rich Plasma infiltration
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Massimo FranchiniItalian National Blood Centre, National Institute of Health, Rome, Italy.
Mario CrucianiItalian National Blood Centre, National Institute of Health, Rome, Italy.
Carlo MengoliItalian National Blood Centre, National Institute of Health, Rome, Italy.
Giuseppe MaranoItalian National Blood Centre, National Institute of Health, Rome, Italy.
Simonetta PupellaItalian National Blood Centre, National Institute of Health, Rome, Italy.
Eva VeropalumboItalian National Blood Centre, National Institute of Health, Rome, Italy.
Francesca MasielloItalian National Blood Centre, National Institute of Health, Rome, Italy.
Ilaria PatiItalian National Blood Centre, National Institute of Health, Rome, Italy.
Stefania VaglioItalian National Blood Centre, National Institute of Health, Rome, Italy.
Giancarlo M LiumbrunoItalian National Blood Centre, National Institute of Health, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this systematic review and meta-analysis was to evaluate the benefit of platelet-rich plasma (PRP) in non-surgical orthopaedic procedures. MATERIAL AND

methodsWe searched the Cochrane Wounds Specialized Register, CENTRAL, MEDLINE (through PUBMED), Embase, and SCOPUS. We also searched clinical trials registries for ongoing and unpublished studies and checked reference lists to identify additional studies.

resultsWe found 36 randomised controlled trials (2,073 patients) that met our inclusion criteria. The included studies mostly had small numbers of participants (from 20 to 225). Twenty-eight studies included patients with lateral epicondylitis or plantar fasciitis. PRP was compared to local steroids injection (19 studies), saline injection (6 studies), autologous whole blood (4 studies), local anaesthetic injection (3 studies), dry needling injection (3 studies), and to other comparators (4 studies). Primary outcomes were pain and function scores, and adverse events. On average, it is unclear whether or not use of PRP compared to controls reduces pain scores and functional score at short- (up to 3 months) and medium- (4-6 months) term follow-up. The available evidence for all the comparisons was rated as very low quality due to inconsistency, imprecision, and risk of bias in most of the selected studies. There were no serious adverse events related to PRP injection or control treatments.

conclusionsThe results of this meta-analysis, which documents the very marginal effectiveness of PRP compared to controls, does not support the use of PRP as conservative treatment in orthopaedics.

Indexed as

Platelet-Rich PlasmaFasciitis, PlantarFemaleHumansMaleOrthopedicsRandomized Controlled Trials as TopicRegistriesTennis Elbow

Identifiers

PMID30201082
PMCPMC6214820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.