ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2018
Blood volume measurement using cardiovascular magnetic resonance and ferumoxytol: preclinical validation.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Feasibility of Magnetic Resonance Imaging-Guided Pulmonary Artery Stenting in a Commercial Wide-Bore 0.55-T Scanner.JACC. Basic to translational science · 2026Article
- Characterizing extravascular lung water-A dual-contrast agent extracellular volume approach by cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Article
- Dynamic contrast-enhanced MR lymphangiography: feasibility of using ferumoxytol in patients with chronic kidney disease.European radiology · 2022Article
- Ferumoxytol-enhanced magnetic resonance T1 reactivity for depiction of myocardial hypoperfusion.NMR in biomedicine · 2021Article
- Estimation of fractional myocardial blood volume and water exchange using ferumoxytol-enhanced magnetic resonance imaging.Journal of magnetic resonance imaging : JMRI · 2021Article
- Article
- Credibility Assessment of a Subject-Specific Mathematical Model of Blood Volume Kinetics for Prediction of Physiological Response to Hemorrhagic Shock and Fluid Resuscitation.Frontiers in physiology · 2021Article
- Effect of ferric-carboxy maltose on oxygen kinetics and functional status in heart failure patients with iron deficiency.Future science OA · 2020Article
- Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Review
- The Role of Cardiac Magnetic Resonance Imaging to Detect Cardiac Toxicity From Cancer Therapeutics.Current treatment options in cardiovascular medicine · 2019Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe hallmark of heart failure is increased blood volume. Quantitative blood volume measures are not conveniently available and are not tested in heart failure management. We assess ferumoxytol, a marketed parenteral iron supplement having a long intravascular half-life, to measure the blood volume with cardiovascular magnetic resonance (CMR).
methodsSwine were administered 0.7 mg/kg ferumoxytol and blood pool T
resultsMean plasma volume estimated by ferumoxytol was 61.9 ± 4.3 ml/kg. After adjustment for hematocrit the resultant mean blood volume was 88.1 ± 9.4 ml/kg, which agreed with carbon monoxide measures (91.1 ± 18.9 ml/kg). Repeated measurements yielded a coefficient of variation of 6.9%, and Bland-Altman repeatability coefficient of 14%. The blood volume estimates with abbreviated protocols yielded small biases (mean differences between 0.01-0.06 L) and strong correlations (r
conclusionsIn this swine model, ferumoxytol CMR accurately measures plasma volume, and with correction for hematocrit, blood volume. Abbreviated protocols can be added to diagnostic CMR examination for heart failure within 8 min.
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