ArticleBMC pulmonary medicine2018
Solid part size is an important predictor of nodal metastasis in lung cancer with a subsolid tumor.
Article in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Diagnosis and selection of surgical approaches for synchronous multiple primary lung cancer: a narrative review.Journal of thoracic disease · 2026Review
- Mediastinal lymph node metastasis pattern of subsolid non-small cell lung cancer.Journal of thoracic disease · 2026Article
- Intratumor Heterogeneity Predicts Prognosis in Lepidic Predominant Lung Adenocarcinoma.Thoracic cancer · 2025Article
- Preoperative computed tomography semantic features in predicting lymph node metastasis of part-solid nodules in non-small cell lung cancer: a multicenter retrospective study.Quantitative imaging in medicine and surgery · 2024Article
- Prediction of the stage shift growth of early-stage lung adenocarcinomas by volume-doubling time.Quantitative imaging in medicine and surgery · 2024Article
- Prognostic Factors of Non-Predominant-Lepidic Lung Adenocarcinoma Presenting as Ground Glass Opacity: Results of a Multicenter Study.Journal of personalized medicine · 2024Article
- Risk factors for mediastinal lymph node metastases in early-stage non-small-cell lung cancer and prediction model establishment.American journal of cancer research · 2024Article
- Development and external validation of a nomogram for predicting lymph node metastasis in 1-3 cm lung adenocarcinoma.Future oncology (London, England) · 2024Article
- Is tumor diameter a risk factor for occult N1 metastasis in patients with peripheral non-small cell lung cancer which is smaller than 3 cm?Updates in surgery · 2023Article
- Nomograms for intraoperative prediction of lymph node metastasis in clinical stage IA lung adenocarcinoma.Cancer medicine · 2023Article
- [Prediction of Lymph Node Metastasis of Mixed Ground-glass Nodules Based on Clinical Imaging Information].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Article
- rhG-CSF is associated with an increased risk of metastasis in NSCLC patients following postoperative chemotherapy.BMC cancer · 2022Article
- Preoperative risk factors of lymph node metastasis in clinical N0 lung adenocarcinoma of 3 cm or less in diameter.BMC surgery · 2022Article
- A predictive nomogram for lymph node metastasis in part-solid invasive lung adenocarcinoma: A complement to the IASLC novel grading system.Frontiers in oncology · 2022Article
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Abstract
backgroundCandidates for preoperative or intraoperative nodal assessment among patients with non-small cell lung cancer (NSCLC) manifesting as a subsolid tumor are not established. The present study was conducted to demonstrate the distribution of nodal metastasis rate according to newly proposed T categories for subsolid tumors, and we further aimed to identify radiologic parameters that can be predictive of nodal metastasis.
methodsWe retrospectively reviewed cases of NSCLC manifesting as a subsolid tumor in computed tomography scans in a university-affiliated tertiary hospital between April 2013 and August 2016. All patients underwent mediastinal lymph node dissection during resection surgery. Multivariate analysis was performed among clinical and radiologic parameters.
resultsOf the 269 eligible patients, T-categories were classified as cTis (n = 23, 8.6%), cT1 (n = 203, 75.5%), and cT2 (n = 43, 16.0%). Ten patients (3.7%) had nodal metastasis: pN1 (n = 5, 1.9%), pN2 (n = 5, 1.9%). Nodal metastasis was not observed in tumors with a solid part ≤1.0 cm (cT1mi and cT1a) or in nonsolid tumors ≤3.0 cm (cTis). The nodal metastasis rate in cT1b, cT1c, and cT2 tumors was 6.1% (4/65), 8.3% (1/12), and 11.7% (5/43), respectively. Multivariate analysis showed that a solid part size > 1.5 cm [odds ratio, 5.89; 95% confidence interval, 1.25-27.68, p = 0.025] was significantly associated with nodal metastasis.
conclusionsWe observed nodal metastasis from cT1b tumors (solid part size > 1 cm) among proposed T categories for subsolid tumors and a solid part size is an important radiologic parameter predictive of nodal metastasis in NSCLC manifesting as a subsolid tumor. Considering the low rate of nodal metastasis, pathologic nodal assessment may be unnecessary in early T category tumors with a small solid part size.
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