ArticleBMC neurology2018
The subtleties of cognitive decline in multiple sclerosis: an exploratory study using hierarchichal cluster analysis of CANTAB results.
Article in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sex differences in psychosocial functioning and neurocognition in bipolar disorder: a systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Computerized neuropsychological assessment devices in multiple sclerosis: A systematic review.Multiple sclerosis (Houndmills, Basingstoke, England) · 2019Pooled it
- Cognitive Performance and Psychological Characteristics in Patients With Clinically Isolated Syndrome: A Case-Control Study.Health science reports · 2026Article
- Toward the Search for Clinical and Cognitive Variables that Affect Employment in LATAM: a Multicenter Study.Journal of occupational rehabilitation · 2026Article
- Regulation of brain iron homeostasis and its influence on cognitive function.European radiology · 2026Article
- Global scale-free brain activity as a potential neural signature of visual information processing in aging.Frontiers in aging neuroscience · 2026Article
- Subtypes of relapsing-remitting multiple sclerosis identified by network analysis.Frontiers in digital health · 2022Article
- The correlation between circulating inflammatory, oxidative stress, and neurotrophic factors level with the cognitive outcomes in multiple sclerosis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Dual-Task Exercise to Improve Cognition and Functional Capacity of Healthy Older Adults.Frontiers in aging neuroscience · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundIt is essential to investigate cognitive deficits in multiple sclerosis (MS) to develop evidence-based cognitive rehabilitation strategies. Here we refined cognitive decline assessment using the automated tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) and hierarchical cluster analysis.
methodsWe searched for groups of distinct cognitive profiles in 35 relapsing-remitting MS outpatients and 32 healthy controls. All individuals participated in an automated assessment (CANTAB) and in a pencil and paper general neuropsychological evaluation.
resultsHierarchical cluster analysis of the CANTAB results revealed two distinct groups of patients based mainly on the Simple Reaction Time (RTI) and on the Mean Latency of Rapid Visual Processing (RVP). The general neuropsychological assessment did not show any statistically significant differences between the cluster groups. Compared to the healthy control group, all MS outpatients had lower scores for RTI, RVP, paired associate learning, and delayed matching to sample. We also analyzed the associations between CANTAB results and age, education, sex, pharmacological treatment, physical activity, employment status, and the Expanded Disability Status Scale (EDSS). Although limited by the small number of observations, our findings suggest a weak correlation between performance on the CANTAB and age, education, and EDSS scores.
conclusionsWe suggest that the use of selected large-scale automated visuospatial tests from the CANTAB in combination with multivariate statistical analyses may reveal subtle and earlier changes in information processing speed and cognition. This may expand our ability to define the limits between normal and impaired cognition in patients with Multiple Sclerosis.
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