Trial reportNutrients2018
Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy Women.
Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- High versus low-added sugar consumption for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2022Pooled it
- Fructose metabolism as an adaptive survival axis in pancreatic cancer: mechanistic insights and therapeutic implications.Frontiers in medicine · 2026Review
- Deciphering cross-cohort metabolic signatures of immune responses and their implications for disease pathogenesis.Molecular systems biology · 2025Article
- Harnessing Metabolomics to Advance Nutrition-Based Therapeutics for Inflammation: A Systematic Review of Randomized Clinical Trials.Metabolites · 2025Review
- Untargeted LC-IMS-qToF-MS-Based Lipidomics Approach to Evaluate the Effect of a Polyphenol-Rich Beverage on Human Lipid Profiles.International journal of molecular sciences · 2025Article
- Rapid Identification ofMolecules (Basel, Switzerland) · 2025Article
- Deciphering metabolic shifts in Gaucher disease type 1: a multi-omics study.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Article
- Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition.JCI insight · 2024Article
- Article
- Dietary Assessment and Metabolomic Methodologies in Human Feeding Studies: A Scoping Review.Advances in nutrition (Bethesda, Md.) · 2023Article
- Metabolic-Associated Fatty Liver Disease and Insulin Resistance: A Review of Complex Interlinks.Metabolites · 2023Review
- Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank.Nature communications · 2023Article
- Distinct patterns of personalised dietary advice delivered by a metabotype framework similarly improve dietary quality and metabolic health parameters: secondary analysis of a randomised controlled trial.Frontiers in nutrition · 2023Article
- Article
- Impact of a long-term high-fructose diet on systemic metabolic profiles of mice.FASEB bioAdvances · 2022Article
- Metabolomic alteration induced by psychotropic drugs: Short-term metabolite profile as a predictor of weight gain evolution.Clinical and translational science · 2021Observational
- Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.Genome biology · 2021Article
- Differences in Clinical and Dietary Characteristics, Serum Adipokine Levels, and Metabolomic Profiles between Early- and Late-Onset Gout.Metabolites · 2021Article
- Disparate Metabolomic Responses to Fructose Consumption between Different Mouse Strains and the Role of Gut Microbiota.Metabolites · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe consumption of high amounts of fructose is associated with metabolic diseases. However, the underlying mechanisms are largely unknown.
objectiveTo determine the effects of high fructose intake on plasma metabolomics. STUDY
designWe enrolled 12 healthy volunteers (six lean and six obese women, age 24⁻35 years) in a crossover intervention study. All participants carried out three diets: (1) low fructose (<10 g/day); (2) high fructose (100 g/day) from natural food sources (fruit); and (3) high fructose (100 g/day) from high fructose syrup (HFS). OUTCOME MEASURES: The primary outcome was changes in plasma metabolites measured by targeted metabolomics.
resultsHigh compared to low fructose diets caused a marked metabolite class separation, especially because of changes in acylcarnitine and lysophosphatidylcholine levels. Both high fructose diets resulted in a decrease in mean acylcarnitine levels in all subjects, and an increase in mean lysophosphatidylcholine and diacyl-phosphatidylcholine levels in obese individuals. Medium chain acylcarnitines were negatively correlated with serum levels of liver enzymes and with the fatty liver index. DISCUSSION: The metabolic shifts induced by high fructose consumption suggest an inhibition of mitochondrial β-oxidation and an increase in lipid peroxidation. The effects tended to be more pronounced following the HFS than the fruit diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.