Evidence map›Paper›PMID 30200630›Full record

ArticleCancers2018

Hung-Chih Hsu, Nina Lapke, Shu-Jen Chen, Yen-Jung Lu, Ren-Shiang Jhou, Chien-Yuh Yeh, Wen-Sy Tsai, Hsin-Yuan Hung, Jason Chia-Hsun Hsieh, Tsai-Sheng Yang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
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  9. Review
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  15. Association ofBioMed research international · 2022
    Article
  16. Article
  17. Article
  18. CirculatingJournal of clinical medicine · 2021
    Article
  19. Article
  20. MicroRNA-Based Therapeutics for Drug-Resistant Colorectal Cancer.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hung-Chih HsuDivision of Hematology/Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan City 333, Taiwan. dannyhsuyoyo@gmail.com.ORCID 0000-0002-4719-4143
Nina LapkeACT Genomics, Neihu Dist., Taipei City 114, Taiwan. ninalapke@actgenomics.com.
Shu-Jen ChenACT Genomics, Neihu Dist., Taipei City 114, Taiwan. sjchen@actgenomics.com.
Yen-Jung LuACT Genomics, Neihu Dist., Taipei City 114, Taiwan. yjlu@actgenomics.com.
Ren-Shiang JhouACT Genomics, Neihu Dist., Taipei City 114, Taiwan. renshiangjhou@actgenomics.com.
Chien-Yuh YehCollege of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan. chnyuh@gmail.com.
Wen-Sy TsaiCollege of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan. wensyt@gmail.com.
Hsin-Yuan HungCollege of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan. hsin3345@gmail.com.
Jason Chia-Hsun HsiehDivision of Hematology/Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan City 333, Taiwan. wisdom5000@gmail.com.
Tsai-Sheng YangDivision of Hematology/Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan City 333, Taiwan. a481124@cgmh.org.tw.
Tan Kien ThiamACT Genomics, Neihu Dist., Taipei City 114, Taiwan. jtchen@actgenomics.com.
Jeng-Fu YouCollege of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan. jenodyssey@gmail.com.
Chang Gung University · TWGenomics Research Center, Academia Sinica · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPG3C1841Chang Gung Memorial Hospital, Linkou CORPG3F0062
6 · The paper itself

Abstract

backgroundBevacizumab-based regimens are used as standard treatments for colorectal cancer. Unfortunately, there are no established predictive markers for bevacizumab response.

methodsTumor samples from 36 metastatic colorectal cancer patients treated with bevacizumab plus chemotherapy were analyzed by next-generation sequencing of all coding exons of more than 400 genes. Single gene and signaling pathway analyses were performed to correlate genomic data with response.

resultsAmong the genes most frequently mutated in our cohort, only mutations in

conclusionDeleterious alterations in

Indexed as

bevacizumab resistancemetastatic colorectal cancernext-generation sequencingPTPRT/PTPRD mutation and deletionVEGF

Identifiers

PMID30200630
PMCPMC6162606
OpenAlexW2890888376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.