Evidence map›Paper›PMID 30200580›Full record

ArticleViruses2018

Evolution of Human Respiratory Syncytial Virus (RSV) over Multiple Seasons in New South Wales, Australia.

Francesca Di Giallonardo, Jen Kok, Marian Fernandez, Ian Carter, Jemma L Geoghegan, Dominic E Dwyer, Edward C Holmes, John-Sebastian Eden

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 41 citations in OpenAlex.

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  9. Genomic characterisation of respiratory syncytial virus: a novel system for whole genome sequencing and full-length G and F gene sequences.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
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  13. RAPIDViruses · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Francesca Di GiallonardoMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. fdigiallonardo@kirby.unsw.edu.au.
Jen KokInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia. jen.kok@health.nsw.gov.au.
Marian FernandezInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia. marian.fernandez@health.nsw.gov.au.
Ian CarterInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia. ian.carter@health.nsw.gov.au.
Jemma L GeogheganDepartment of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia. jemma.geoghegan@mq.edu.au.ORCID 0000-0003-0970-0153
Dominic E DwyerInstitute for Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia. dominic.dwyer@sydney.edu.au.
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. edward.holmes@sydney.edu.au.ORCID 0000-0001-9596-3552
John-Sebastian EdenMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. js.eden@sydney.edu.au.ORCID 0000-0003-1374-3551
The University of Sydney · AUMacquarie University · AU

Funding

Australian Research Council FL170100022
6 · The paper itself

Abstract

There is an ongoing global pandemic of human respiratory syncytial virus (RSV) infection that results in substantial annual morbidity and mortality. In Australia, RSV is a major cause of acute lower respiratory tract infections (ALRI). Nevertheless, little is known about the extent and origins of the genetic diversity of RSV in Australia, nor the factors that shape this diversity. We have conducted a genome-scale analysis of RSV infections in New South Wales (NSW). RSV genomes were successfully sequenced for 144 specimens collected between 2010⁻2016. Of these, 64 belonged to the RSVA and 80 to the RSVB subtype. Phylogenetic analysis revealed a wide diversity of RSV lineages within NSW and that both subtypes evolved rapidly in a strongly clock-like manner, with mean rates of approximately 6⁻8 × 10

Indexed as

Evolution, MolecularGenetic VariationCluster AnalysisGenome, ViralHumansMolecular EpidemiologyMutation RateNew South WalesPhylogenyRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsSequence HomologyWhole Genome Sequencingevolutionmulti-year persistencephylogeneticsrespiratory syncytial virus

Identifiers

PMID30200580
PMCPMC6164696
OpenAlexW2890896486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.