Evidence map›Paper›PMID 30200551›Full record

ArticleMolecules (Basel, Switzerland)2018

Liposomes Loaded with Cisplatin and Magnetic Nanoparticles: Physicochemical Characterization, Pharmacokinetics, and In-Vitro Efficacy.

Alfonso Toro-Cordova, Mario Flores-Cruz, Jaime Santoyo-Salazar, Ernesto Carrillo-Nava, Rafael Jurado, Pavel A Figueroa-Rodriguez, Pedro Lopez-Sanchez, Luis A Medina, Patricia Garcia-Lopez

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Review
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  8. Article
  9. Magnetic Nanoparticle Composites: Synergistic Effects and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  10. Review
  11. Advanced pharmaceutical bulletin · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Alfonso Toro-CordovaLaboratorio de Farmacología, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, 14080 CDMX, Mexico. alfonso.toro@hotmail.com.
Mario Flores-CruzLaboratorio de Farmacología, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, 14080 CDMX, Mexico. qfb_mariofc@yahoo.com.mx.
Jaime Santoyo-SalazarDepartamento de Física, Centro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional, CINVESTAV-IPN, Zacatenco, 07360 CDMX, Mexico. jsantoyo@fis.cinvestav.mx.ORCID 0000-0003-3051-7118
Ernesto Carrillo-NavaLaboratorio de Biofisicoquímica, Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, 014510 CDMX, Mexico. ernesto.carrillo@unam.mx.
Rafael JuradoLaboratorio de Farmacología, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, 14080 CDMX, Mexico. fcojl@yahoo.com.
Pavel A Figueroa-RodriguezUnidad de Investigación Biomédica en Cáncer INCan-UNAM, Instituto Nacional de Cancerología, 14080 CDMX, Mexico. figueroa.pav@gmail.com.
Pedro Lopez-SanchezSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340 CDMX, Mexico. pelosa651018@yahoo.com.
Luis A MedinaUnidad de Investigación Biomédica en Cáncer INCan-UNAM, Instituto Nacional de Cancerología, 14080 CDMX, Mexico. medina@fisica.unam.mx.
Patricia Garcia-LopezLaboratorio de Farmacología, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, 14080 CDMX, Mexico. pgarcia_lopez@yahoo.com.mx.
Instituto Nacional de Cancerología · MXCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXInstituto Politécnico Nacional · MXUniversidad Nacional Autónoma de México · MX

Funding

Universidad Nacional Autónoma de México IN209916
6 · The paper itself

Abstract

With the aim improving drug delivery, liposomes have been employed as carriers for chemotherapeutics achieving promising results; their co-encapsulation with magnetic nanoparticles is evaluated in this work. The objective of this study was to examine the physicochemical characteristics, the pharmacokinetic behaviour, and the efficacy of pegylated liposomes loaded with cisplatin and magnetic nanoparticles (magnetite) (Cis-MLs). Cis-MLs were prepared by a modified reverse-phase evaporation method. To characterize their physicochemical properties, an evaluation was made of particle size, ζ-potential, phospholipid and cholesterol concentration, phase transition temperature (

Indexed as

Drug Delivery SystemsAnimalsCell SurvivalCisplatinDrug LiberationHeLa CellsHumansLiposomesMagnetite NanoparticlesNeoplasmsPolyethylene GlycolsRatsRats, WistarCisplatinLiposomesMagnetite NanoparticlesPolyethylene Glycolscancercisplatindrug deliveryliposomes pharmacokineticsmagnetite

Identifiers

PMID30200551
PMCPMC6225157
OpenAlexW2890307114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.