ArticleInternational journal of environmental research and public health2018
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS).
Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Environmental Exposure to Per- and Polyfluorylalkyl Substances (PFASs) and Reproductive Outcomes in the General Population: A Systematic Review of Epidemiological Studies.International journal of environmental research and public health · 2024Pooled it
- Systematic review of associations of polychlorinated biphenyl (PCB) exposure with declining semen quality in support of the derivation of reference doses for mixture risk assessments.Environmental health : a global access science source · 2022Pooled it
- Persistent organic pollutants and couple fecundability: a systematic review.Human reproduction update · 2021Pooled it
- Risk Assessment of PFAS-Induced Male Reproductive Toxicity: A Comprehensive Evaluation Using the TRAEC Strategy.Environment & health (Washington, D.C.) · 2026Article
- In utero and childhood exposure to organochlorines and perfluorinated chemicals in relation to sperm aneuploidy in adulthood.Environmental health : a global access science source · 2026Article
- In utero and childhood exposure to organochlorines and perfluorinated chemicals in relation to sperm aneuploidy in adulthood.Research square · 2025Article
- Exploring the mechanism of PFTrDA on human hepatic metabolic diseases based on network toxicology and molecular docking.Scientific reports · 2025Article
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Perfluoroundecanoic Acid Inhibits Liver Cell Development in Pubertal Male Rats via Inducing Oxidative Stress.ACS omega · 2025Article
- Article
- Per- and polyfluoroalkyl substances (PFAS), thyroid hormones, sexual hormones and pubertal development in adolescents residing in the neighborhood of a 3M factory.Environmental health : a global access science source · 2025Article
- In vivo gamete toxicology in the context of in vitro fertilization: a narrative review.F&S reviews · 2025Article
- Key recommendations and research priorities of the 2021 AMAP human health assessment.International journal of circumpolar health · 2024Article
- Cross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans.The Science of the total environment · 2024Review
- PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics.Seminars in reproductive medicine · 2024Review
- In-Vitro Effects of Perfluorooctanoic Acid on Human Sperm Function: What Are the Clinical Consequences?Journal of clinical medicine · 2024Article
- Polychlorinated Biphenyls and Semen Quality in Healthy Young Men Living in a Contaminated Area.Toxics · 2023Article
- Associations of Prenatal Per- and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Body Composition at 16-20 Years of Age: Project Viva.Environmental health perspectives · 2023Article
- Endocrine-disrupting chemicals and male reproductive health.Fertility and sterility · 2023Review
- PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies.Current pollution reports · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposure were associated with abnormalities in semen quality or reproductive hormones in Faroese men. This population based cross-sectional study includes 263 Faroese men (24⁻26 years) who delivered a semen sample for assessment of sperm concentration, total sperm count, semen volume, morphology and motility. A blood sample was drawn and analyzed for reproductive hormones, PCBs and PFASs. Exposure to ∑PCBs and perfluorooctane sulfonate (PFOS) was positively associated with sex hormone-binding globulin (SHBG) and luteinizing hormone (LH). In addition, total testosterone (T) was positively associated with ∑PCB. Both PCBs and PFOS appear to lead to increased SHBG, perhaps mediated via the liver. The higher total T associated with PCB may represent a compensatory adaption to elevated SHBG levels to maintain an unchanged free testosterone concentration. The positive association to LH for both PCBs and PFOS may indicate a direct adverse effect on the testosterone producing Leydig cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.