Evidence map›Paper›PMID 30200232›Full record

ArticleBiomolecules2018

Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the Community-The Gutenberg Health Study.

Christoph Niekamp, Dorothee Atzler, Francisco M Ojeda, Christoph R Sinning, Karl J Lackner, Rainer H Böger, Thomas Munzel, Manfred E Beutel, Irene Schmidtmann, Norbert Pfeiffer and 6 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Christoph NiekampDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20251 Hamburg, Germany. christophniekamp@gmx.de.
Dorothee AtzlerDeutsches Zentrum für Herz-Kreislauf-Forschung e.V. (DZHK), Partner Site Munich, 80336 Munich, Germany. dorothee.atzler@med.uni-muenchen.de.
Francisco M OjedaDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20251 Hamburg, Germany. f.ojeda-echevarria@uke.de.
Christoph R SinningDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20251 Hamburg, Germany. c.sinning@uke.de.
Karl J LacknerCenter for Cardiovascular Research (DZHK), Partner Site Rhein/Main, 55131 Mainz, Germany. Karl.Lackner@unimedizin-mainz.de.
Rainer H BögerDepartment of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246 Hamburg, Germany. boeger@uke.de.
Thomas MunzelCenter for Cardiovascular Research (DZHK), Partner Site Rhein/Main, 55131 Mainz, Germany. tmuenzel@uni-mainz.de.
Manfred E BeutelDept Psychosomat Med & Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany. Manfred.Beutel@unimedizin-mainz.de.
Irene SchmidtmannInstitute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany. Irene.Schmidtmann@unimedizin-mainz.de.
Norbert PfeifferDept Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany. norbert.pfeiffer@unimedizin-mainz.de.
Anja LeuschnerCenter for Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany. Anja.Leuschner@unimedizin-mainz.de.
Stefan BlankenbergDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20251 Hamburg, Germany. s.blankenberg@uke.de.
Philipp S WildCenter for Cardiovascular Research (DZHK), Partner Site Rhein/Main, 55131 Mainz, Germany. Philipp.Wild@unimedizin-mainz.de.
Tanja ZellerDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20251 Hamburg, Germany. t.zeller@uke.de.
Edzard SchwedhelmCenter for Cardiovascular Research (DZHK), Partner Site Rhein/Main, 55131 Mainz, Germany. schwedhelm@uke.de.
Renate B SchnabelDepartment of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20251 Hamburg, Germany. r.schnabel@uke.de.
Johannes Gutenberg University Mainz · DEUniversität Hamburg · DEGerman Centre for Cardiovascular Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homoarginine has come into the focus of interest as a biomarker for cardiovascular disease. Atrial fibrillation (AF) causes a substantial increase in morbidity and mortality. Whether circulating homoarginine is associated with occurrence or persistence of AF and may serve as a new predictive biomarker remains unknown. We measured plasma levels of homoarginine in the population-based Gutenberg health study (3761 patients included, of them 51.7% males), mean age 55.6 ± 10.9 years-old. Associations between homoarginine and intermediate electrocardiographic and echocardiographic phenotypes and manifest AF were examined. Patients with AF (124 patients, of them 73.4% males) had a mean age 64.8 ± 8.6 years-old compared to a mean age of 55.3 ± 10.9 in the population without AF (

Indexed as

Health SurveysPhenotypeResidence CharacteristicsAgedAtrial FibrillationCase-Control StudiesCross-Sectional StudiesElectrocardiographyFemaleHomoarginineHumansMaleMiddle AgedRisk FactorsHomoarginineatrial fibrillationbiomarkerdiastolic disfunctionhomoargininepopulation-based cohort

Identifiers

PMID30200232
PMCPMC6165554
OpenAlexW2889452267

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.