Evidence map›Paper›PMID 30200211›Full record

ArticleMarine drugs2018

Anticoagulant and Antithrombotic Properties of Three Structurally Correlated Sea Urchin Sulfated Glycans and Their Low-Molecular-Weight Derivatives.

Ariana A Vasconcelos, Isabela D Sucupira, Alessandra L Guedes, Ismael N Queiroz, Flavia S Frattani, Roberto J Fonseca, Vitor H Pomin

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Dihydrogeodin fromMarine drugs · 2025
    Article
  2. Current medicinal chemistry · 2025
    Article
  3. Review
  4. The Sea CucumberJournal of natural products · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Marine Antithrombotics.Marine drugs · 2020
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Ariana A VasconcelosProgram of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, RJ, Brazil. arianaavasconcelos@gmail.com.
Isabela D SucupiraProgram of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, RJ, Brazil. isabela.sucupira@gmail.com.
Alessandra L GuedesProgram of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, RJ, Brazil. alessandra.guedes@bioqmed.ufrj.br.
Ismael N QueirozProgram of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, RJ, Brazil. mael.nilo@hotmail.com.
Flavia S FrattaniDepartment of Clinical Analyses and Toxicology, School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil. flaviafrattani@pharma.ufrj.br.
Roberto J FonsecaUniversity Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, RJ, Brazil. robertofonseca@hucff.ufrj.br.
Vitor H PominProgram of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, RJ, Brazil. vpomin@olemiss.edu.ORCID 0000-0002-5015-8880
Universidade Federal do Rio de Janeiro · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico Universal 442311/2014-1
6 · The paper itself

Abstract

The anticoagulant and antithrombotic properties of three structurally correlated sea urchin-derived 3-linked sulfated α-glycans and their low molecular-weight derivatives were screened comparatively through various in vitro and in vivo methods. These methods include activated partial thromboplastin time, the inhibitory activity of antithrombin over thrombin and factor Xa, venous antithrombosis, the inhibition of platelet aggregation, the activation of factor XII, and bleeding. While the 2-sulfated fucan from

Indexed as

AdultAnimalsAnticoagulantsDisease Models, AnimalDrug Evaluation, PreclinicalFactor XaFactor XIIFemaleFibrinolytic AgentsHealthy VolunteersHumansMaleMolecular StructureMolecular WeightPartial Thromboplastin TimePolysaccharidesAnticoagulantsFactor XaFactor XIIFibrinolytic AgentsPolysaccharidesSulfatesThromboplastinanticoagulationantithrombosismarine glycansulfated fucansulfated galactan

Identifiers

PMID30200211
PMCPMC6163371
OpenAlexW2889391400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.