SynthesisMedicine2018
Relationship between dyslipidemia and diabetic retinopathy: A systematic review and meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Worldwide Prevalence of Dyslipidemia in Diabetes: An Umbrella Overview of the Meta-Analysis StudiesEndocrine, metabolic & immune disorders drug targets · 2026Pooled it
- Association between dyslipidaemia and dry eye disease: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Relationship between dyslipidemia and diabetic retinopathy in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.Systematic reviews · 2023Pooled it
- Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.Eye (London, England) · 2022Pooled it
- Article
- Intermittent Fasting and Risk of Diabetic Retinopathy: Retrospective Data from the National Health and Nutrition Examination Survey.Nutrients · 2026Article
- Neurodegenerative and Glial Physiology in Diabetic Retinopathy: Dissociated Effects of Forskolin on Neuronal Survival and Glial Activation.Biomedicines · 2026Article
- Targeting CDH13 as a therapeutic strategy to mitigate pathological ocular angiogenesis.Journal of translational medicine · 2026Article
- Diabetic Retinopathy Prevalence and Incidence in Zimbabwe: The Feasibility of Digital Fundoscopy Screening.Journal of diabetes research · 2026Observational
- Lipidomic analysis of vitreous humor derived from patients with proliferative diabetic retinopathy.BMC ophthalmology · 2025Article
- Evaluating lipid-lowering drug targets for full-course diabetic retinopathy.The British journal of ophthalmology · 2025Article
- Diabetic retinopathy and dyslipidemia among patients with type 2 diabetes mellitus in the Jazan endocrine and diabetes center: A case-control study.Journal of family medicine and primary care · 2025Article
- Apolipoprotein and menopausal status are significant influencing factors for diabetic retinopathy in type II diabetes mellitus women.Scientific reports · 2025Article
- New Markers for the Assessment of Microvascular Complications in Patients with Metabolic Syndrome.Metabolites · 2025Review
- Development and Validation of a Machine Learning Algorithm for Predicting Diabetes Retinopathy in Patients With Type 2 Diabetes: Algorithm Development Study.JMIR medical informatics · 2025Article
- Associations between lipid abnormalities and diabetic retinopathy across a large United States national database.Eye (London, England) · 2024Article
- Modulating effects of crocin on lipids and lipoproteins: Mechanisms and potential benefits.Heliyon · 2024Review
- The Beneficial Effects of Curcumin on Lipids: Possible Effects on Dyslipidemia-induced Cardiovascular Complications.Current medicinal chemistry · 2024Review
- Role of Oxysterols in Ocular Degeneration Mechanisms and Involvement of P2X7 Receptor.Advances in experimental medicine and biology · 2024Article
- Potential impact of epicardial fat thickness, pentraxin-3, and high-sensitive C-reactive protein on the risk of non-proliferative diabetic retinopathy.Journal of diabetes and metabolic disorders · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between serum lipids and diabetic retinopathy (DR) was controversial. Therefore, we performed a meta-analysis to evaluate the relationship between triglycerides (TG), serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), and DR.
methodsA systematic review and meta-analysis of observational studies was carried out to explore the association between serum lipids and DR. Studies related were initially indentified by searching PubMed, Cochrane Library, and Elsevier databases through June, 2017. Then a manual retrieval was also performed. RevMan 5.3 software was used to calculate the pooled mean differences (MDs) and related 95% confidence intervals (CIs). To test the stability of the final results, a sensitivity analysis was also performed.
resultsA total of 7 studies were included in this meta-analysis. When compared with the controls, the DR cases did not show significantly higher TG levels (MD 9.18 mg/dL, 95%CI -4.14 to 22.49, P = .18), higher TC levels (MD 3.77 mg/dL, 95%CI: -2.45 to 9.98, P = .24), as well as lower HDL-C levels (MD -1.14 mg/dL, 95%CI: -2.43 to 0.15, P = .08). But slightly higher LDL-C levels were observed (MD 3.74 mg/dL, 95%CI: 0.13-7.35, P = .04). In addition, whether serum lipids involved in the progression of DR were relatively unexplored, but fenofibrate was confirmed to benefit the DR cases.
conclusionsBased on recent published data, we did not find obvious differences in TG, TC, and HDL-C levels between patients with DR and without DR. However, slightly higher LDL-C levels were observed in the DR cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.