ArticleRedox biology2018
Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway.
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Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
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Who cites it
50 citing papers in PubMed, 74 citations in OpenAlex.
- Connexin 26 in Hearing Health and Disease: StructuralFoundations, Mutation Mechanisms, and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Recent Progress in Mechanism-Based Therapies forInternational journal of molecular sciences · 2026Review
- Connexin Regulation and Modulation of Neural Stem Cell Differentiation Induced by Cell-Permeable Itaconate.Journal of cellular physiology · 2026Article
- Upregulation of TRPV2 exacerbates age-related hearing loss by promoting oxidative stress in spiral ganglion neurons.Molecular brain · 2026Article
- Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Autophagy in Sensorineural Hearing Loss: Jekyll or Hyde?International journal of molecular sciences · 2026Review
- Engineered Inner Ear Drug Delivery Systems for Hearing Loss Treatment.Research (Washington, D.C.) · 2026Review
- Cochlear endoplasmic reticulum stress causes connexin 26 degradation is involved in age-related hearing loss.iScience · 2025Article
- Connexins in Acquired Hearing Loss: Expanding Research Perspectives.Biomedicines · 2025Review
- Article
- Connexin hemichannel blockade by abEC1.1 disrupts glioblastoma progression, suppresses invasiveness, and reduces hyperexcitability in preclinical models.Cell communication and signaling : CCS · 2025Article
- Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review.Frontiers in aging neuroscience · 2025Review
- Beyond the auditory system: cognitive implications of age-related hearing loss.Frontiers in aging neuroscience · 2025Review
- Deficient Gap Junction Coupling in Two Common Hearing Loss-Related Variants of GJB2.Clinical and experimental otorhinolaryngology · 2024Article
- A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment.Antioxidants (Basel, Switzerland) · 2024Review
- The human OPA1Cellular and molecular life sciences : CMLS · 2024Article
- Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto/neurotoxicity.Journal of neuroinflammation · 2024Article
- [Distribution characteristics and correlation analysis ofLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Review
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Authors and funding
23 authors at 8 institutions in 2 countries.
Anna Rita FetoniCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy; Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy; Institute of Otolaryngology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo F. Vito 1, 00168 Rome, Italy.
Veronica ZorziCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy; Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
Fabiola PacielloCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy; Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
Gaia ZiraldoCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy; Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
Chiara PeresCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy.
Marcello RaspaCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy.
Ferdinando ScavizziCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy.
Anna Maria SalvatoreCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy.
Giulia CrispinoCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy.
Gabriella TognolaCNR Institute of Electronics, Computer and Telecommunication Engineering, 20133 Milano, Italy.
Giulia GentileCNR Institute of Neurological Sciences, 95126 Catania, Italy.
Antonio Gianmaria SpampinatoCNR Institute of Neurological Sciences, 95126 Catania, Italy.
Denis CuccaroCNR Institute of Neurological Sciences, 95126 Catania, Italy.
Maria GuarnacciaCNR Institute of Neurological Sciences, 95126 Catania, Italy.
Giovanna MorelloCNR Institute of Neurological Sciences, 95126 Catania, Italy.
Guy Van CampCenter of Medical Genetics, University of Antwerp and Antwerp University Hospital, Universiteitsplein 1, 2610 Antwerp, Belgium.
Erik FransenDepartment of Biomedical Sciences, University of Antwerp, 2650 Antwerp, Belgium.
Marco BrumatDept Med Surg & Hlth Sci, University of Trieste, Trieste, Italy; IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy.
Giorgia GirottoDept Med Surg & Hlth Sci, University of Trieste, Trieste, Italy; IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy.
Gaetano PaludettiUniversità Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy; Institute of Otolaryngology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo F. Vito 1, 00168 Rome, Italy.
Paolo GaspariniDept Med Surg & Hlth Sci, University of Trieste, Trieste, Italy; IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy. Electronic address: paolo.gasparini@burlo.trieste.it.
Sebastiano CavallaroCNR Institute of Neurological Sciences, 95126 Catania, Italy. Electronic address: sebastiano.cavallaro@cnr.it.
Fabio MammanoCNR Institute of Cell Biology and Neurobiology, Monterotondo 00015, Italy; University of Padova, Department of Physics and Astronomy "G. Galilei", Padova, Italy. Electronic address: fabio.mammano@cnr.it.
Institute of Cell Biology and Neurobiology · ITInstitute of Neurological Sciences · ITUniversità Cattolica del Sacro Cuore · ITIRCCS Materno Infantile Burlo Garofolo · ITAntwerp University Hospital · BEInstitute of Electronics, Computer and Telecommunication Engineering · ITUniversity of Antwerp · BEUniversity of Trieste · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in GJB2, the gene that encodes connexin 26 (Cx26), are the most common cause of sensorineural hearing impairment. The truncating variant 35delG, which determines a complete loss of Cx26 protein function, is the prevalent GJB2 mutation in several populations. Here, we generated and analyzed Gjb2
Indexed as
Signal TransductionAnimalsApoptosisConnexin 26FemaleGene DeletionMaleMiceMice, Inbred C57BLNF-E2-Related Factor 2Oxidation-ReductionPresbycusisConnexin 26Nfe2l2 protein, mouseNF-E2-Related Factor 2Age-related hearing lossConnexin 26Genome-wide association studyHair cellsMouse modelsSpiral ganglion neurons
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.