ArticleAmerican journal of respiratory and critical care medicine2019
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.
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Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15citing papers in PubMed, 1 pooled it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.The American journal of clinical nutrition · 2024Pooled it
- Polyunsaturated fatty acids modulation of smoking-related epigenetics and pulmonary outcomes.Genes & nutrition · 2026Article
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- Revealing Causal Protein Biomarkers and Potential Therapeutic Targets for Histologic-Specific Lung Cancer.Journal of cellular and molecular medicine · 2025Article
- A comprehensive investigation of the relationship between dietary fatty acid intake and preserved ratio impaired spirometry: multimethodology based on NHANES.Lipids in health and disease · 2025Article
- The relationship of fish oil supplements and plasma fatty acids with lung function decline.European journal of nutrition · 2025Article
- Nutrition, Lifestyle, and Environmental Factors in Lung Homeostasis and Respiratory Health.Nutrients · 2025Review
- Associations of Plasma Omega-3 Fatty Acids With Progression and Survival in Pulmonary Fibrosis.Chest · 2024Article
- Investigating Associations of Omega-3 Fatty Acids, Lung Function Decline, and Airway Obstruction.American journal of respiratory and critical care medicine · 2023Article
- The Protective Effect of Omega-3 Fatty Acids in Attenuating Lung Function Decline.American journal of respiratory and critical care medicine · 2023Article
- Omega-3 Fatty Acids Interact withNutrients · 2023Article
- Investigating associations of omega-3 fatty acids, lung function decline, and airway obstruction.medRxiv : the preprint server for health sciences · 2023Article
- Dietary intake and plasma concentrations of PUFAs in childhood and adolescence in relation to asthma and lung function up to adulthood.The American journal of clinical nutrition · 2022Article
- Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease.American journal of epidemiology · 2021Article
- Associations of ω-3 Fatty Acids With Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults.American journal of epidemiology · 2021Article
Corrections and comments
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Authors and funding
50 authors at 19 institutions in 8 countries.
Jiayi Xu1 Division of Nutritional Sciences, Cornell University, Ithaca, New York.ORCID 0000-0001-6379-386X
Nathan C Gaddis2 Research Computing Division.
Traci M Bartz3 Department of Biostatistics.
Ruixue Hou5 Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina.
Ani W Manichaikul6 Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Nathan Pankratz7 Department of Laboratory Medicine and Pathology and.
Albert V Smith8 Department of Biostatistics, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0003-1942-5845
Fangui Sun9 Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Natalie Terzikhan10 Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Christina A Markunas12 Center for Omics Discovery and Epidemiology, Behavioral Health Research Division, and.
Bonnie K Patchen1 Division of Nutritional Sciences, Cornell University, Ithaca, New York.
Matthew Schu13 Genomics in Public Health and Medicine Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, North Carolina.
May A Beydoun14 Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
Guy G Brusselle10 Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Gudny Eiriksdottir16 Icelandic Heart Association, Kopavogur, Iceland.
Xia Zhou17 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.
Alexis C Wood18 USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas.
Mariaelisa Graff19 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Tamara B Harris14 Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
M Arfan Ikram11 Department of Epidemiology.
David R Jacobs17 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.
Lenore J Launer14 Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
Rozenn N Lemaitre4 Cardiovascular Health Research Unit.
George T O'Connor21 The Pulmonary Center, Department of Medicine.
Elizabeth C Oelsner22 Department of Medicine, Columbia University, New York, New York.
Bruce M Psaty4 Cardiovascular Health Research Unit.
Ramachandran S Vasan26 Division of Cardiology and Preventive Medicine, Department of Medicine, and.ORCID 0000-0001-7357-5970
Rebecca R Rohde19 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Stephen S Rich6 Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Jerome I Rotter28 Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.
Sudha Seshadri30 Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.
Lewis J Smith31 Division of Pulmonary and Critical Care, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-4728-1562
Henning Tiemeier11 Department of Epidemiology.ORCID 0000-0002-4395-1397
Michael Y Tsai7 Department of Laboratory Medicine and Pathology and.
André G Uitterlinden11 Department of Epidemiology.
V Saroja Voruganti5 Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina.
Hanfei Xu9 Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Nuno R Zilhão16 Icelandic Heart Association, Kopavogur, Iceland.
Myriam Fornage34 Institute of Molecular Medicine and.
M Carola Zillikens37 Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Stephanie J London38 Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina.ORCID 0000-0003-4911-5290
R Graham Barr22 Department of Medicine, Columbia University, New York, New York.
Josée Dupuis9 Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Sina A Gharib20 Department of Medicine.
Vilmundur Gudnason16 Icelandic Heart Association, Kopavogur, Iceland.
Lies Lahousse11 Department of Epidemiology.ORCID 0000-0002-3494-4363
Kari E North19 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Lyn M Steffen17 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.
Patricia A Cassano1 Division of Nutritional Sciences, Cornell University, Ithaca, New York.ORCID 0000-0003-4827-5073
Dana B Hancock12 Center for Omics Discovery and Epidemiology, Behavioral Health Research Division, and.ORCID 0000-0003-2240-3604
RTI International · USBoston University · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · USNational Institutes of Health · USCornell University · USErasmus MC · NLUniversity of Washington · USColumbia University · USGhent University Hospital · BEKaiser Permanente Washington Health Research Institute · USUniversity of Virginia · USChildren's Nutrition Research Center at Baylor College of Medicine · USIcelandic Heart Association · ISInstitute of Molecular Medicine · INNorthwestern University · USThe Lundquist Institute · USUniversity of Iceland · ISUniversity of Michigan · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
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Abstract
rationaleOmega-3 polyunsaturated fatty acids (n-3 PUFAs) have anti-inflammatory properties that could benefit adults with comprised pulmonary health.
objectiveTo investigate n-3 PUFA associations with spirometric measures of pulmonary function tests (PFTs) and determine underlying genetic susceptibility.
methodsAssociations of n-3 PUFA biomarkers (α-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid [DPA], and docosahexaenoic acid [DHA]) were evaluated with PFTs (FEV
resultsDPA and DHA were positively associated with FEV
conclusionsWe corroborated beneficial effects of n-3 PUFAs on pulmonary function. By modeling genome-wide n-3 PUFA interactions, we identified a novel DPP10 SNP association with FVC that was not detectable in much larger studies ignoring this interaction.
Indexed as
Agedalpha-Linolenic AcidBiomarkersDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedFemaleForced Expiratory VolumeGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRespiratory Physiological Phenomenaalpha-Linolenic AcidBiomarkersDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDocosahexaenoic Acidsdocosapentaenoic acidDPP10 protein, humanEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedFEVFVCgenome-wide association studyomega-3 fatty acidssmoking
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