Evidence map›Paper›PMID 30199416›Full record

ArticleEpidemiology (Cambridge, Mass.)2019

Traffic-related Air Pollution and Pregnancy Loss.

Marianthi-Anna Kioumourtzoglou, Raanan Raz, Ander Wilson, Ronen Fluss, Ronit Nirel, David M Broday, Yuval, Michele R Hacker, Thomas F McElrath, Itamar Grotto and 2 more

Abstract read
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Short- and intermediate-term exposure to NOEnvironmental pollution (Barking, Essex : 1987) · 2020
    Pooled it
  3. Article
  4. Article
  5. A novel approach for inferring effects on pregnancy loss.American journal of epidemiology · 2025
    Article
  6. Article
  7. Article
  8. Associations of climatic factors with pregnancy loss in Nicosia, Cyprus.Journal of exposure science & environmental epidemiology · 2025
    Article
  9. Article
  10. Article
  11. Analysis of gasoline-related pollutant exposures and risks in California between 1996 and 2014.Journal of exposure science & environmental epidemiology · 2024
    Article
  12. Article
  13. Article
  14. Time series analysis in environmental epidemiology: challenges and considerations.International journal of occupational medicine and environmental health · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Quantifying diurnal changes in NOHygiene and environmental health advances · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Marianthi-Anna KioumourtzoglouFrom the Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY.
Raanan RazBraun School of Public Health and Community Medicine, The Hebrew University of Jerusalem Jerusalem, Israel.
Ander WilsonDepartment of Statistics, Colorado State University Fort Collins, CO.
Ronen FlussBraun School of Public Health and Community Medicine, The Hebrew University of Jerusalem Jerusalem, Israel.
Ronit NirelDepartment of Statistics, The Hebrew University of Jerusalem Jerusalem, Israel.
David M BrodayFaculty of Civil and Environmental Engineering, Technion, Israel Institute of Technology, Haifa, Israel.
YuvalFaculty of Civil and Environmental Engineering, Technion, Israel Institute of Technology, Haifa, Israel.
Michele R HackerDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, MA.
Thomas F McElrathDivision of Maternal-Fetal Medicine, Brigham & Women's Hospital, Harvard Medical School Boston, MA.
Itamar GrottoBen-Gurion University of the Negev, Beer Sheva, Israel.
Petros KoutrakisDepartment of Environmental Health, Harvard T.H. Chan School of Public Health Boston, MA.
Marc G WeisskopfDepartment of Epidemiology, Harvard T.H. Chan School of Public Health Boston, MA.
Hebrew University of Jerusalem · ILTechnion – Israel Institute of Technology · ILBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USColorado State University · USColumbia University · USHarvard University · USIsrael Ministry of Health · IL

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
Air Pollution and Autism in Israel: A Population-Wide StudyR21ES026900 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI WEISSKOPF, MARC G · 2016 to 2017
$391k
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R21 ES026900NIEHS NIH HHS T32 ES007069
6 · The paper itself

Abstract

backgroundTraffic-related air pollution has been linked to multiple adverse pregnancy outcomes. However, few studies have examined pregnancy loss, targeting losses identified by hospital records, a large limitation as it does not capture events not reported to the medical system.

methodsWe used a novel variation of the time-series design to determine the association, and identify the critical window of vulnerability, between week-to-week traffic-related air pollution and conceptions resulting in live births, using nitrogen dioxide (NO2) as a traffic emissions tracer. We used information from all live births recorded at Beth Israel Deaconess Medical Center in Boston, MA (2000-2013) and all live births in Tel Aviv District, Israel (2010-2013).

resultsIn Boston (68,969 live births), the strongest association was during the 15th week of gestation; for every 10 ppb of NO2 increase during that week, we observed a lower rate of live births (rate ratio [RR] = 0.87; 95% confidence interval [CI], 0.78, 0.97), using live birth-identified conceptions to infer pregnancy losses. In the Tel Aviv District (95,053 live births), the strongest estimate was during the 16th gestational week gestation (RR = 0.82; 95% CI, 0.76, 0.90 per 10 ppb of NO2).

conclusionsUsing weekly conceptions ending in live birth rather than identified pregnancy losses, we comprehensively analyzed the relationship between air pollution and all pregnancy loss throughout gestation. The observed results, with remarkable similarity in two independent locations, suggest that higher traffic-related air pollution levels are associated with pregnancy loss, with strongest estimates between the 10th and 20th gestational weeks.

Indexed as

Traffic-Related PollutionAbortion, SpontaneousBostonEnvironmental MonitoringFemaleHumansIsraelLive BirthNitrogen DioxidePregnancyRetrospective StudiesNitrogen Dioxide

Identifiers

PMID30199416
PMCPMC6269216
OpenAlexW2891667145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.