SynthesisJournal of toxicology and environmental health. Part B, Critical reviews2018
Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance.
Synthesis in Journal of toxicology and environmental health. Part B, Critical reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- An Umbrella Review of Meta-Analyses Evaluating Associations between Human Health and Exposure to Major Classes of Plastic-Associated Chemicals.Annals of global health · 2024Pooled it
- Gestational benzyl butyl phthalate exposure impairs sperm capacitation in F1 offspring by altering PKA-associated signaling and tyrosine phosphorylation.Archives of toxicology · 2026Article
- Associations of endocrine disrupting chemicals with anogenital distance across infancy.The Journal of clinical endocrinology and metabolism · 2026Observational
- Plastic Pollution and Child Health: A Narrative Review of Micro- and Nanoplastics, Additives, and Developmental Risks.Journal of clinical medicine · 2025Review
- Prenatal phthalate exposure and anogenital distance in infants at 12 months.Environment international · 2025Article
- Endocrine disruption and male reproductive disorders: unanswered questions.Human reproduction (Oxford, England) · 2024Review
- Association between prenatal phthalate exposure and ano-genital indices among offsprings in an Israeli cohort.Heliyon · 2024Article
- Prenatal phthalate exposure and fetal penile length and width.Pediatric research · 2024Article
- Prenatal DEHP exposure induces lifelong testicular toxicity by continuously interfering with steroidogenic gene expression.Translational andrology and urology · 2024Article
- Environmentally relevant DEHP exposure during gestational and lactational period inhibits filamin a testicular expression.Journal of molecular histology · 2023Article
- Associations of maternal anthropometrics with newborn anogenital distance and the 2:4 digit ratio.Human reproduction (Oxford, England) · 2022Article
- Whole blood analysis for medical diagnostics by GC-MS with Cold EI.Journal of mass spectrometry : JMS · 2022Article
- Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures.Reproduction (Cambridge, England) · 2022Article
- Prenatal phthalate exposure in relation to placental corticotropin releasing hormone (pCRH) in the CANDLE cohort.Environment international · 2022Article
- A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat.Environment international · 2021Article
- Buy-now-pay-later: Hazards to human and planetary health from plastics production, use and waste.Journal of paediatrics and child health · 2021Article
- REPRODUCTIVE TOXICOLOGY: Environmental exposures, fetal testis development and function: phthalates and beyond.Reproduction (Cambridge, England) · 2021Review
- COVID-19 discarded disposable gloves as a source and a vector of pollutants in the environment.Journal of hazardous materials · 2021Review
- Prenatal and early childhood exposure to phthalates and childhood behavior at age 7 years.Environment international · 2020Article
- Androgens and the masculinization programming window: human-rodent differences.Biochemical Society transactions · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 12 institutions in 2 countries.
Funding
Abstract
Male reproductive alterations found in animals and humans following in utero phthalate exposure include decreased anogenital distance (AGD) and other reproductive-tract malformations. The aim of this investigation was to conduct systematic reviews of human and animal evidence of the effect of in utero exposure to diethylhexyl phthalate (DEHP) on anogenital distance (AGD) in males. PubMed, Embase, and Toxline were searched for relevant human and experimental animal studies on August 15, 2016. Search results were screened for relevance, and studies that met the inclusion criteria were evaluated for quality and data extracted for analysis. Confidence in the human and animal bodies of evidence was assessed and hazard conclusions reached by integrating evidence streams. The search yielded 6 relevant human studies and 19 animal studies. Meta-analysis of 5 human observational prospective cohort studies showed that increased maternal urinary concentrations of DEHP metabolites were associated with decreased AGD in boys (-4.07 [CI, -6.49 to -1.66] % decrease per log
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.