ArticleJournal of Alzheimer's disease : JAD2018
Aβ42/Aβ40 and Aβ42/Aβ38 Ratios Are Associated with Measures of Gait Variability and Activities of Daily Living in Mild Alzheimer's Disease: A Pilot Study.
Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Association between high plasma p-tau181 level and gait changes in patients with mild cognitive impairment.Scientific reports · 2025Article
- Association between nutritional status and gait performance in Alzheimer's disease.CNS neuroscience & therapeutics · 2024Article
- Objective Physical Function in the Alzheimer's Disease Continuum: Association with Cerebrospinal Fluid Biomarkers in the ALBION Study.International journal of molecular sciences · 2023Article
- Advances and applications of fluids biomarkers in diagnosis and therapeutic targets of Alzheimer's disease.CNS neuroscience & therapeutics · 2023Review
- Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans.Journal of Alzheimer's disease : JAD · 2023Article
- Mobility and associations with levels of cerebrospinal fluid amyloid β and tau in a memory clinic cohort.Frontiers in aging neuroscience · 2023Article
- Article
- Slowing gait speed precedes cognitive decline by several years.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Bias-generating factors in biofluid amyloid-β measurements for Alzheimer's disease diagnosis.Biomedical engineering letters · 2021Review
- The Diagnostic Potential of Amyloidogenic Proteins.International journal of molecular sciences · 2021Review
- Secondary Prevention of Dementia: Combining Risk Factors and Scalable Screening Technology.Frontiers in neurology · 2021Review
- Quantitative Measurement of Cerebrospinal Fluid Amyloid-β Species by Mass Spectrometry.Journal of Alzheimer's disease : JAD · 2021Article
- Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults.Alzheimer's research & therapy · 2020Article
- Flexible nanopillar-based immunoelectrochemical biosensor for noninvasive detection of Amyloid beta.Nano convergence · 2020Article
- Advantages and Pitfalls in Fluid Biomarkers for Diagnosis of Alzheimer's Disease.Journal of personalized medicine · 2020Review
- Role of Body-Fluid Biomarkers in Alzheimer's Disease Diagnosis.Diagnostics (Basel, Switzerland) · 2020Review
- Gait Disturbances are Associated with Increased Cognitive Impairment and Cerebrospinal Fluid Tau Levels in a Memory Clinic Cohort.Journal of Alzheimer's disease : JAD · 2020Article
- Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers.Experimental & molecular medicine · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 9 institutions in 3 countries.
Funding
Abstract
Gait disturbances are some of the earliest changes in dementia and their monitoring presents an opportunity for early diagnosis. The exact relationship between gait and well-established biomarkers of Alzheimer's disease (AD) remains to be clarified. In this study we compared gait-related measures with cerebrospinal fluid (CSF) markers of AD pathology. We recruited seventeen participants with mild AD in a multi-site study and performed gait assessment as well as lumbar punctures to obtain CSF. CSF Aβ42/Aβ40 and Aβ42/Aβ38 correlated positively with measures of variability (step time and step length) in the clinic-based assessments. This was driven by a negative relationship between gait variability and Aβ40 and Aβ38 but not Aβ42.The amyloid ratios and gait variability measures were also associated with more severe functional impairment. We interpret these data as an indication that increasing amyloid production (i.e., increasing Aβ40 and Aβ38) is associated with diminishing cognitive-motor control of gait. These preliminary results suggest that the two amyloid ratios may be a marker of the earliest disturbances in the interplay between cognitive and motor control which characterize dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.