Evidence map›Paper›PMID 30198324›Full record

ArticleJournal of diabetes science and technology2019

Development and Implementation of a Subcutaneous Insulin Clinical Decision Support Tool for Hospitalized Patients.

Nestoras Mathioudakis, Rebecca Jeun, Gerald Godwin, Annette Perschke, Swaytha Yalamanchi, Estelle Everett, Peter Greene, Amy Knight, Christina Yuan, Sherita Hill Golden

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Association Between Daily Insulin Dose Adjustments and Glycemic Control in Noncritically Ill Hospitalized Hyperglycemic Patients: A Retrospective Cohort Study.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
    Article
  3. Inpatient Insulin Dosing Calculators.Diabetes spectrum : a publication of the American Diabetes Association · 2025
    Article
  4. Article
  5. Article
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  8. Article
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  10. Article
  11. Inpatient Hypoglycemia: The Challenge Remains.Journal of diabetes science and technology · 2020
    Review
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  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Nestoras Mathioudakis1 Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rebecca Jeun1 Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gerald Godwin2 Epic Information Technology Team, Johns Hopkins Health System, Baltimore, MD, USA.
Annette Perschke3 Nursing Administration, Clinical Informatics, Johns Hopkins Hospital, Baltimore, MD, USA.
Swaytha Yalamanchi1 Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Estelle Everett1 Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter Greene4 Johns Hopkins Hospital, Baltimore, MD, USA.
Amy Knight5 Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.
Christina Yuan6 Armstrong Institute for Patient Safety and Quality, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sherita Hill Golden1 Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USJohns Hopkins Hospital · USJohns Hopkins Medicine · USJohns Hopkins Bayview Medical Center · USNational Patient Safety Foundation · US

Funding

Implementation and Evaluation of a Real-Time Informatics Alert to Prevent Insulin-Associated Hypoglycemia in the HospitalK23DK111986 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MATHIOUDAKIS, NESTORAS N · 2016 to 2019
$796k
NIDDK NIH HHS K23 DK111986
6 · The paper itself

Abstract

backgroundInsulin is one of the highest risk medications used in hospitalized patients. Multiple complex factors must be considered in determining a safe and effective insulin regimen. We sought to develop a computerized clinical decision support (CDS) tool to assist hospital-based clinicians in insulin management.

methodsAdapting existing clinical practice guidelines for inpatient glucose management, a design team selected, configured, and implemented a CDS tool to guide subcutaneous insulin dosing in non-critically ill hospitalized patients at two academic medical centers that use the EpicCare® electronic medical record (EMR). The Agency for Healthcare Research and Quality (AHRQ) best practices in CDS design and implementation were followed.

resultsA CDS tool was developed in the form of an EpicCare SmartForm, which generates an insulin regimen by integrating information about the patient's body weight, diabetes type, home and hospital insulin requirements, and nutritional status. Total daily recommended insulin doses are distributed into respective basal and nutritional doses with a tailored correctional insulin scale. Preimplementation, several approaches were used to communicate this new tool to clinicians, including emails, lectures, and videos. Postimplementation, a support team was available to address user technical issues. Feedback from stakeholders has been used to continuously refine the tool. Inclusion of the programming in the EMR vendor's community library has allowed dissemination of the tool outside our institution.

conclusionsWe have developed an EMR-based tool to guide SQ insulin dosing in non-critically ill hospitalized patients. Further studies are needed to evaluate adoption and clinical effectiveness of this intervention.

Indexed as

HospitalizationInfusion Pumps, ImplantableInsulin Infusion SystemsSoftwareAlgorithmsDecision Support Systems, ClinicalDiabetes MellitusDrug Delivery SystemsFemaleHumansImplementation ScienceInfusions, SubcutaneousInsulinMaleRetrospective StudiesSubcutaneous TissueInsulinclinical decision support systemsdiabetes mellitushospital management insulinsubcutaneous (SQ)

Identifiers

PMID30198324
PMCPMC6501530
OpenAlexW2890269267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.