Evidence map›Paper›PMID 30198104›Full record

ArticleNephrology (Carlton, Vic.)2019

Development and future deployment of a 5 years allograft survival model for kidney transplantation.

Derek A DuBay, Zemin Su, Thomas A Morinelli, Prabhakar Baliga, Vinayak Rohan, John Bian, David Northrup, Nicole Pilch, Vinaya Rao, Titte R Srinivas and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nephrology (Carlton, Vic.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Surrogate Endpoints for Late Kidney Transplantation Failure.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Article
  8. Costs in the Year Following Deceased Donor Kidney Transplantation: Relationships With Renal Function and Graft Failure.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Derek A DuBayDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Zemin SuDivision of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston, South Carolina, USA.
Thomas A MorinelliDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID https://orcid.org/0000-0002-3929-7863
Prabhakar BaligaDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Vinayak RohanDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
John BianDivision of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston, South Carolina, USA.
David NorthrupOffice of the Chief Information Officer, Medical University of South Carolina, Charleston, South Carolina, USA.
Nicole PilchDepartment of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, South Carolina, USA.
Vinaya RaoDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Titte R SrinivasIntermountain Transplant Services, Salt Lake City, Utah, USA.
Patrick D MauldinDivision of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston, South Carolina, USA.
David J TaberDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Medical University of South Carolina · USIntermountain Healthcare · US

Funding

Increasing African American Organ Donation: Donor Registration & Family ConsentK23DK091514 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DUBAY, DEREK A. · 2012 to 2016
$1.0M
A pragmatic video intervention to promote African American organ donor registration at the Department of Motorized VehiclesR03DK106432 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DUBAY, DEREK A. · 2015 to 2016
$147k
National Institutes of Health K23DK091514National Institutes of Health R03DK106432NIDDK NIH HHS K23 DK091514NIDDK NIH HHS R03 DK106432
6 · The paper itself

Abstract

aimIdentifying kidney transplant patients at highest risk for graft loss prior to loss may allow for effective interventions to improve 5 years survival.

methodsWe performed a 10 years retrospective cohort study of adult kidney transplant recipients (n = 1747). We acquired data from electronic health records, United Network of Organ Sharing, social determinants of health, natural language processing data extraction, and real-time capture of dynamically evolving clinical data obtained within 1 year of transplant; from which we developed a 5 years graft survival model.

resultsTotal of 1439 met eligibility; 265 (18.4%) of them experienced graft loss by 5 years. Graft loss patients were characterized by: older age, being African-American, diabetic, unemployed, smokers, having marginal donor kidneys and cardiovascular comorbidities. Predictive dynamic variables included: low mean blood pressure, higher pulse pressures, higher heart rate, anaemia, lower estimated glomerular filtration rate peak, increased tacrolimus variability, rejection and readmissions. This Big Data analysis generated a 5 years graft loss model with an 82% predictive capacity, versus 66% using baseline United Network of Organ Sharing data alone.

conclusionOur analysis yielded a 5 years graft loss model demonstrating superior predictive capacity compared with United Network of Organ Sharing data alone, allowing post-transplant individualized risk-assessed care prior to transitioning back to community care.

Indexed as

Graft SurvivalKidney TransplantationModels, StatisticalAdultCohort StudiesFemaleForecastingGraft RejectionHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentTime FactorsTransplantation, Homologousdata analysisdecision support techniquegraft survivalkidneytransplant

Identifiers

PMID30198104
PMCPMC6408984
OpenAlexW2889594617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.