Evidence map›Paper›PMID 30198055›Full record

ArticleInternational journal of bipolar disorders2018

Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study.

Ole Kristian Drange, Arne Einar Vaaler, Gunnar Morken, Ole Andreas Andreassen, Ulrik Fredrik Malt, Per Ivar Finseth

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bipolar disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00201526 (Bipolar Research And Innovation Network - BRAIN), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00201526 recruitingnot on this map

Bipolar Research And Innovation Network - BRAIN

TypeobservationalSponsorNorwegian University of Science and TechnologyRan2003 to 2030Enrolled3,000ConditionsBipolar Disorder
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Contributing risk factors of common psychiatric disorders in the Pakistani population.European archives of psychiatry and clinical neuroscience · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ole Kristian DrangeDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway. ole.kristian.drange@gmail.com.ORCID http://orcid.org/0000-0003-2766-7190
Arne Einar VaalerDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Gunnar MorkenDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Ole Andreas AndreassenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ulrik Fredrik MaltInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Per Ivar FinsethDepartment of Brøset, Division of Mental Health Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Norwegian University of Science and Technology · NOOslo University Hospital · NOSt Olav's University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbout one in ten diagnosed with bipolar disorder (BD) has experienced a premorbid traumatic brain injury (TBI), while not fulfilling the criteria of bipolar and related disorder due to another medical condition (BD due to TBI). We investigated whether these patients have similar clinical characteristics as previously described in BD due to TBI (i.e. more aggression and irritability and an increased hypomania/mania:depression ratio) and other distinct clinical characteristics.

methodsFive hundred five patients diagnosed with BD type I, type II, or not otherwise specified, or cyclothymia were interviewed about family, medical, and psychiatric history, and assessed with the Young Mania Rating Scale (YMRS) and the Inventory of Depressive Symptoms Clinician Rated 30 (IDS-C

resultsPremorbid TBI was associated with a higher YMRS disruptive component score (OR 1.7, 95% CI 1.1-2.4, p = 0.0077) and more comorbid migraine (OR 4.6, 95% CI 1.9-11, p = 0.00090) independently of several possible confounders. Items on disruptive/aggressive behaviour and irritability had the highest loadings on the YMRS disruptive component. Premorbid TBI was not associated with an increased hypomania/mania:depression ratio.

conclusionsDisruptive symptoms and comorbid migraine characterize BD with premorbid TBI. Further studies should examine whether the partial phenomenological overlap with BD due to TBI could be explained by a continuum of pathophysiological effects of TBI across the diagnostic dichotomy. Trial registration ClinicalTrials.gov: NCT00201526. Registered September 2005 (retrospectively registered).

Indexed as

Bipolar disorderBrain injuriesDiagnosisIrritable moodMigraine disordersPrincipal component analysis

Identifiers

PMID30198055
PMCPMC6162005
OpenAlexW2886076176

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.