Evidence map›Paper›PMID 30197985›Full record

ArticleKidney international reports2018

Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study.

Ruth F Dubin, Suzanne Judd, Rebecca Scherzer, Michael Shlipak, David G Warnock, Mary Cushman, Mark Sarnak, Chirag Parikh, Michael Bennett, Neil Powe and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  8. Review
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  11. Observational
  12. Article
  13. Review
  14. Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs.International journal of environmental research and public health · 2019
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Ruth F DubinDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Suzanne JuddDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Rebecca ScherzerDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Michael ShlipakDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
David G WarnockDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mary CushmanDepartment of Medicine, University of Vermont, Colchester, Vermont, USA.
Mark SarnakDepartment of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.
Chirag ParikhDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Michael BennettDepartment of Pediatrics, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
Neil PoweDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Carmen A PeraltaDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USUniversity of Alabama at Birmingham · USCincinnati Children's Hospital Medical Center · USTufts University · USUniversity of Vermont · USYale University · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Identifying Modifiable Biomarkers/Mediators for Cardiovascular Disease in Chronic Kidney DiseaseU01DK108809 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEO, RAJAT, DUBIN, RUTH · 2016 to 2020
$1.9M
Novel Echocardiographic Methods to Characterize Heart Failure in ESRDR03DK104013 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBIN, RUTH · 2015 to 2016
$142k
NIDDK NIH HHS R03 DK104013NIDDK NIH HHS U01 DK108809NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

introductionUrinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury. In persons with reduced estimated glomerular filtration rate (eGFR) and albuminuria who are at high risk for end-stage renal disease (ESRD) and death, the associations of these urinary markers with incident ESRD or death is an area of active investigation.

methodsAmong 1472 black and white participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study with eGFR ≤60 ml/min per 1.73 m

resultsThere were 257 ESRD events and 819 deaths over a median follow-up of 5.7 and 6.5 years, respectively. In demographic adjusted models, higher levels of uNGAL were associated with increased risk of ESRD and death, but these associations were attenuated in fully adjusted models including baseline eGFR for both ESRD (hazard ratio [HR] = 1.06 per doubling, 95% confidence interval [CI] 0.98-1.14) and death (HR = 1.04, 95% CI = 1.00-1.08). Higher levels of uKIM-1 were associated with increased risk of ESRD and death in demographic-adjusted models, and although attenuated in fully adjusted models, remained statistically significant for both ESRD (HR = 1.24 per doubling, 95% CI = 1.08-1.42) and death (HR = 1.10, 95% CI =1.03-1.19).

conclusionIn this cohort of high-risk patients with baseline eGFR ≤60 ml/min per 1.73 m

Indexed as

chronic kidney diseaseend-stage renal diseasetubular injuryurinary KIM-1urinary NGAL

Identifiers

PMID30197985
PMCPMC6127450
OpenAlexW2808942639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.