Evidence map›Paper›PMID 30197974›Full record

ArticleKidney international reports2018

Risk Factors for Adverse Fetal Outcome in Hemodialysis Pregnant Women.

Claudio Luders, Silvia Maria Titan, Soubhi Kahhale, Rossana Pulcineli Francisco, Marcelo Zugaib

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Guideline
  2. Dialysis and Pregnancy: Optimizing Therapy for Best Maternal and Fetal Outcomes.Hemodialysis international. International Symposium on Home Hemodialysis · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Kidney disease and reproductive health.Nature reviews. Nephrology · 2025
    Review
  12. Article
  13. Article
  14. Management of Pregnancy in Persons with Kidney Failure Treated with Hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2023
    Article
  15. Article
  16. [Outcome of neonates born to mothers with chronic kidney disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Claudio LudersNephrology Division, Sao Paulo University Medical School, Sao Paulo, Brazil.
Silvia Maria TitanNephrology Division, Sao Paulo University Medical School, Sao Paulo, Brazil.
Soubhi KahhaleObstetrics and Gynecology Department, Sao Paulo University Medical School, Sao Paulo, Brazil.
Rossana Pulcineli FranciscoObstetrics and Gynecology Department, Sao Paulo University Medical School, Sao Paulo, Brazil.
Marcelo ZugaibObstetrics and Gynecology Department, Sao Paulo University Medical School, Sao Paulo, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPregnancy in women on dialysis is associated with a higher risk of adverse events, and the best care for this population remains to be established.

methodsIn this series, we aimed to identify factors associated with the risk of adverse fetal outcomes among 93 pregnancies in women on hemodialysis. Dialysis dose was initially assigned according to the presence of residual diuresis, body weight, and years on dialysis. Subsequent adjustments on dialysis dose were performed according to several parameters.

resultsThe overall successful delivery rate was 89.2%, with a dialysis regimen of 2.6 ± 0.7 h/d, 15.4 ± 4.0 h/wk, and mean weekly standard urea Kt/V of 3.3 ± 0.6. In the logistic models, preeclampsia, lupus, primigravida, and average midweek blood urea nitrogen (BUN) level were positively related to the risk of a composite outcome of perinatal death or extreme prematurity, whereas polyhydramnios was inversely related to it. In multivariable linear regression, preeclampsia, polyhydramnios, primigravida, average midweek BUN, and residual diuresis remained significantly and independently related to fetal weight, which is a surrogate marker of fetal outcome. An average midweek BUN of 35 mg/dl was the best value for discriminating the composite outcome, and BUN ≥35 mg/dl was associated with a significant difference in a Kaplan-Meier curve (

conclusionOur results showed that a good fetal outcome could be reached and that preeclampsia, lupus, primigravida, residual diuresis, polyhydramnios, and hemodialysis dose were important variables associated with this outcome. In addition, we suggested that a midweek BUN <35 mg/dl might be used as a target for adjusting dialysis dose until hard data were generated.

Indexed as

chronic kidney diseasefetal outcomeshemodialysishemodialysis adequacypreeclampsiapregnancy

Identifiers

PMID30197974
PMCPMC6127404
OpenAlexW2802822229

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.