ArticleTranslational vision science & technology2018
Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography.
Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Light-induced modifications of the outer retinal hyperreflective layers on spectral-domain optical coherence tomography in humans: an experimental study.Acta ophthalmologica · 2021Trial
- Phase-sensitive photothermal optical coherence tomography: decoupling optical and thermal tissue properties.Biomedical optics express · 2026Article
- Self-Assembly 4-Butylresorcinol Deep Eutectic Solvent Nanoparticles for Efficient Transdermal Delivery and Whitening.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Retinochoroidal and Optic Nerve Head Microstructural and Microvascular Age-Related Changes in Healthy Eyes.Diagnostics (Basel, Switzerland) · 2025Article
- Artificial neural network for enhancing signal-to-noise ratio and contrast in photothermal optical coherence tomography.Scientific reports · 2024Article
- Photothermal optical coherence tomography for 3D live cell detection and mapping.Optics continuum · 2023Article
- Label-free photothermal optical coherence microscopy to locate desired regions of interest in multiphoton imaging of volumetric specimens.Scientific reports · 2023Article
- Optical Coherence Tomography Is a Promising Tool for Zebrafish-Based Research-A Review.Bioengineering (Basel, Switzerland) · 2022Review
- Longitudinal investigation of a xenograft tumor zebrafish model using polarization-sensitive optical coherence tomography.Scientific reports · 2022Article
- Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries.Biomedical optics express · 2022Article
- Non-interferometric volumetric imaging in living human retina by confocal oblique scanning laser ophthalmoscopy.Biomedical optics express · 2022Article
- Non-destructive characterization of adult zebrafish models using Jones matrix optical coherence tomography.Biomedical optics express · 2022Article
- Optical coherence tomography as an alternative tool for evaluating the effects of glyphosate on hybrid catfish (Toxicology reports · 2022Article
- Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography.Journal of biomedical optics · 2022Article
- The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques.Frontiers in medicine · 2022Review
- Transient-mode photothermal optical coherence tomography.Optics letters · 2021Article
- Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography.Journal of biomedical optics · 2021Review
- Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics.Bioactive materials · 2021Article
- Melanins as Sustainable Resources for Advanced Biotechnological Applications.Global challenges (Hoboken, NJ) · 2021Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeTo demonstrate and validate that photothermal optical coherence tomography (PT-OCT) can image melanin in the retinal pigment epithelium (RPE) and can observe light-driven melanosome translocation in the zebrafish retina.
methodsA commercial spectral domain OCT system was modified to perform both OCT and PT-OCT. Four adult tyrosinase-mosaic zebrafish with varying levels of melanin expression across their retinas were imaged, and the PT-OCT signal for pigmented and nonpigmented regions were compared. Wild-type dark-adapted (
resultsA significant increase in PT-OCT signal (
conclusionsPT-OCT can detect different levels of melanin absorption and characterize pigment distribution in the zebrafish retina, including intracellular changes due to light-driven melanosome translocation within the RPE. TRANSLATIONAL RELEVANCE: PT-OCT could quantify changes in pigmentation that occur in retinal diseases. The functional information provided by PT-OCT may also enable a better understanding of the anatomical features within conventional OCT images.
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Registered trials
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