Evidence map›Paper›PMID 30197820›Full record

ArticleProceedings. IEEE International Conference on Bioinformatics and Biomedicine2017

Mining FDA resources to compute population-specific frequencies of adverse drug reactions.

Aleksandar Poleksic, Carson Turner, Rishabh Dalal, Paul Gray, Lei Xie

Abstract read
In one paragraph

Article in Proceedings. IEEE International Conference on Bioinformatics and Biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Exploring Landscape of Drug-Target-Pathway-Side Effect Associations.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aleksandar PoleksicDepartment of Computer Science, University of Northern Iowa, Cedar Falls, USA.
Carson TurnerDepartment of Computer Science, University of Northern Iowa, Cedar Falls, USA.
Rishabh DalalDepartment of Computer Science, University of Northern Iowa, Cedar Falls, USA.
Paul GrayDepartment of Computer Science, University of Northern Iowa, Cedar Falls, USA.
Lei XieDepartment of Computer Science, Hunter College and CUNY Graduate Center, New York, USA.

Funding

Omics data integration and analysis for structure-based multi-target drug designR01GM122845 · NIGMS · NORTHEASTERN UNIVERSITY · PI Lei Xie · 2017 to 2026
$3.0M
Drug discovery by integrating chemical genomics and structural systems biologyR01LM011986 · NLM · HUNTER COLLEGE · PI BRINKMAN, FIONA, BURLEY, STEPHEN K · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM122845NLM NIH HHS R01 LM011986
6 · The paper itself

Abstract

Adverse drug reactions (ADRs) represent one of the main health and economic problems in the world. With increasing data on ADRs, there is an increased need for software tools capable of organizing and storing the information on drug-ADR associations in a form that is easy to use and understand. Here we present a step by step computational procedure capable of extracting drug-ADR frequency data from the large collection of patient safety reports stored in the Federal Drug Administration database. Our procedure is the first of its type capable of generating population specific drug-ADR frequencies. The drug-ADR data generated by our method can be made specific to a single patient population group (such as gender or age) or a single therapy characteristic (such as drug dosage, duration of therapy) or any combination of such.

Indexed as

ADRadverse drug reactioncase reportFDAside-effect

Identifiers

PMID30197820
PMCPMC6128702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.