ArticleJournal of pathology informatics2018
Conventional Microscopical versus Digital Whole-Slide Imaging-Based Diagnosis of Thin-Layer Cervical Specimens: A Validation Study.
Article in Journal of pathology informatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relevance of the College of American Pathologists guideline for validating whole slide imaging for diagnostic purposes to cytopathology.Cytopathology : official journal of the British Society for Clinical Cytology · 2023Pooled it
- Improved Post-Processing Framework for Whole Slide Imaging and 3D Reconstruction.Microscopy research and technique · 2026Article
- Viability of Whole-Slide Imaging for Intraoperative Touch Imprint Cytological Diagnosis of Axillary Sentinel Lymph Nodes in Breast Cancer Patients.Diagnostic cytopathology · 2025Article
- Cultivating Clinical Clarity through Computer Vision: A Current Perspective on Whole Slide Imaging and Artificial Intelligence.Diagnostics (Basel, Switzerland) · 2022Review
- Current and future direction in treatment of HPV-related cervical disease.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Validation of digital microscopy: Review of validation methods and sources of bias.Veterinary pathology · 2022Review
- Lost in digitization - A systematic review about the diagnostic test accuracy of digital pathology solutions.Journal of pathology informatics · 2022Review
- BestCyte® Cell Sorter Imaging System: Primary and adjudicative whole slide image rescreening review times of 500 ThinPrep Pap test thin-layers - An intra-observer, time-surrogate analysis of diagnostic confidence potentialities.Journal of pathology informatics · 2022Article
- The histopathological diagnosis of atypical meningioma: glass slide versus whole slide imaging for grading assessment.Virchows Archiv : an international journal of pathology · 2021Article
- DPA-ESDIP-JSDP Task Force for Worldwide Adoption of Digital Pathology.Journal of pathology informatics · 2021Article
- Automated Cervical Digitized Histology Whole-Slide Image Analysis Toolbox.Journal of pathology informatics · 2021Article
- Recommendations for pathologic practice using digital pathology: consensus report of the Korean Society of Pathologists.Journal of pathology and translational medicine · 2020Review
- Whole Slide Imaging (WSI) in Pathology: Current Perspectives and Future Directions.Journal of digital imaging · 2020Review
- Being fully digital: perspective of a Dutch academic pathology laboratory.Histopathology · 2019Review
- Article
- Twenty Years of Digital Pathology: An Overview of the Road Travelled, What is on the Horizon, and the Emergence of Vendor-Neutral Archives.Journal of pathology informatics · 2018Review
- Frozen section telepathology service: Efficiency and benefits of an e-health policy in South Tyrol.Digital healthArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhole-slide imaging (WSI) has been implemented in many areas of pathology, but primary diagnostics of cytological specimens are lagging behind. One of the objectives of viewing scanned whole-slide images from histological or cytological specimens is remote exchange of knowledge and expertise of professionals to increase diagnostic accuracy. We compared the scoring results of our team obtained in double readings of two different data sets: conventional light microscopy (CLM) versus CLM and CLM versus WSI. We hypothesized that WSI is noninferior to CLM for primary diagnostics of thin-layer cervical slides. MATERIALS AND
methodsFirst, we determined the concordance rate at different thresholds of the participating cytotechnicians by double reading with CLM of 500 thin-layer cervical slides (Cohort 1). Next, CLM was compared with WSI examination of another 505 thin-layer cervical slides (Cohort 2) scanned at ×20 in single focus plane. Finally, all major discordant cases of Cohort 1 were evaluated by an external expert in the field of gynecological cytology and of Cohort 2 in the weekly case meetings.
resultsThe overall concordance rate of Cohort 1 (CLM vs. CLM) was 97.8% (95% confidence interval [CI]: 96.0%-98.7%) and of Cohort 2 was 95.3% (95% CI: 93.0%-96.9%).
conclusionConcordance rates of WSI versus CLM were comparable with those of CLM versus CLM. We have made a step forward paving the road to implementation of WSI also in routine diagnostic cytology.
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