Evidence map›Paper›PMID 30197639›Full record

ArticleFrontiers in immunology2018

Transcriptomic Characterization of a Chicken Embryo Model Infected With Duck Hepatitis A Virus Type 1.

Jinyan Xie, Qiurui Zeng, Mingshu Wang, Xumin Ou, Yunchao Ma, Anchun Cheng, Xin-Xin Zhao, Mafeng Liu, Dekang Zhu, Shun Chen and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Mapping QTLs for Breast Muscle Weight in an FLife (Basel, Switzerland) · 2021
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Jinyan XieInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Qiurui ZengSchool of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Mingshu WangInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Xumin OuInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Yunchao MaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Anchun ChengInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Xin-Xin ZhaoInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Mafeng LiuInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Dekang ZhuKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, China.
Shun ChenInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Renyong JiaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Qiao YangInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Ying WuInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Shaqiu ZhangInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Yunya LiuInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Yanling YuInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Ling ZhangInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Xiaoyue ChenInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Sichuan Agricultural University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duck hepatitis A virus type 1 (DHAV-1) is one of the most common and lethal pathogens in young ducklings. Live-attenuated DHAV vaccine (CH60 strain) developed by passaging in chicken embryos provided effective immune protection for ducklings. However, the accurate mechanism for such adaption in chicken embryos is not fully revealed. Here, we utilize RNA-sequencing to perform global transcriptional analysis of DHAV-1-innoculated embryonated livers along with histopathological and ultrastructural analysis. This study revealed that infection with DHAV-1 strain CH60 is associated with enhanced type I and II interferon responses, activated innate immune responses, elevated levels of suppressor of cytokine signaling 1 and 3 (

Indexed as

Hepatitis Virus, DuckTranscriptomeAnimalsApoptosisChick EmbryoComputational BiologyDucksGene Expression ProfilingGene Expression RegulationHepatitis, Viral, AnimalImmunity, InnateLiverMethylationPhenotypePicornaviridae InfectionsSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling 3 Proteinchicken embryo modelsDuck hepatitis A virus type 1innate immune systemSOCStranscriptomic analysis

Identifiers

PMID30197639
PMCPMC6117380
OpenAlexW2888251530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.