Evidence map›Paper›PMID 30197629›Full record

ArticleFrontiers in microbiology2018

Pockets of HIV Non-infection Within Highly-Infected Risk Networks in Athens, Greece.

Leslie D Williams, Evangelia-Georgia Kostaki, Eirini Pavlitina, Dimitrios Paraskevis, Angelos Hatzakis, John Schneider, Pavlo Smyrnov, Andria Hadjikou, Georgios K Nikolopoulos, Mina Psichogiou and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Leslie D WilliamsInstitute for Infectious Disease Research, National Development and Research Institutes, New York, NY, United States.
Evangelia-Georgia KostakiDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Eirini PavlitinaTransmission Reduction Intervention Project, Athens, Greece.
Dimitrios ParaskevisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Angelos HatzakisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
John SchneiderDepartments of Medicine and Public Health Sciences, University of Chicago Medical Center, Center for AIDS Elimination, Chicago, IL, United States.
Pavlo SmyrnovAlliance for Public Health, Kyiv, Ukraine.
Andria HadjikouMedical School, University of Cyprus, Nicosia, Cyprus and European University Cyprus, Nicosia, Cyprus.
Georgios K NikolopoulosMedical School, University of Cyprus, Nicosia, Cyprus.
Mina PsichogiouFirst Department of Internal Medicine, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Samuel R FriedmanInstitute for Infectious Disease Research, National Development and Research Institutes, New York, NY, United States.
National and Kapodistrian University of Athens · GRNational Development and Research Institutes · USUniversity of Cyprus · CYAlliance for Public Health · UALaiko General Hospital of Athens · GRUniversity of Chicago Medical Center · US

Funding

Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan, Courtney McKnight · 1998 to 2026
$38.9M
Preventing HIV Transmission by Recently-Infected Drug UsersDP1DA034989 · NIDA · NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC. · PI FRIEDMAN, SAMUEL R · 2012 to 2016
$3.8M
NIDA NIH HHS DP1 DA034989NIDA NIH HHS P30 DA011041
6 · The paper itself

Abstract

As part of a network study of HIV infection among people who inject drugs (PWID) and their contacts, we discovered a connected subcomponent of 29 uninfected PWID. In the context of a just-declining large epidemic outbreak, this raised a question: What explains the existence of large pockets of uninfected people? Possible explanations include "firewall effects" (Friedman et al., 2000; Dombrowski et al., 2017) wherein the only HIV+ people that the uninfected take risks with have low viral loads; "bottleneck effects" wherein few network paths into the pocket of non-infection exist; low levels of risk behavior; and an impending outbreak. We considered each of these. Participants provided information on their enhanced sexual and injection networks and assisted us in recruiting network members. The largest connected component had 241 members. Data on risk behaviors in the last 6 months were collected at the individual level. Recent infection was determined by LAg (Sedia

Indexed as

bottleneck effectsfirewall effectsHIV riskHIV transmissionnetworksnon-infection

Identifiers

PMID30197629
PMCPMC6117409
OpenAlexW2888720187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.