Evidence map›Paper›PMID 30197627›Full record

ArticleFrontiers in endocrinology2018

Central Precocious Puberty in a Child With Metachromatic Leukodystrophy.

Gilda Belli, Emanuele Bartolini, Andrea Bianchi, Mario Mascalchi, Stefano Stagi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gilda BelliDepartment of Health Sciences, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy.
Emanuele BartoliniNeurology Unit and Laboratories, Anna Meyer Children's University Hospital, Florence, Italy.
Andrea BianchiPediatric Neuroradiology, Anna Meyer Children's University Hospital, Florence, Italy.
Mario MascalchiPediatric Neuroradiology, Anna Meyer Children's University Hospital, Florence, Italy.
Stefano StagiDepartment of Health Sciences, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy.
University of Florence · ITMeyer Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metachromatic leucodystrophy (MLD) is a rare inherited lysosomal disorder caused by reduced activity of the enzyme arylsulfatase A with accumulation of sulfatides in the nervous system. We report a female child affected by MLD who developed central precocious puberty (CPP). This association has not been described so far. The proposita, after normal growth and psychomotor development, at age of 30 months presented with a rapidly progressive gait disturbance with frequent falls and with loss of acquired language skills. Magnetic resonance imaging showed leukoencephalopathy. Biochemical blood essays showed a 91% reduction in the arylsulfatase A activity and genetic analysis revealed compound heterozygous mutations of the

Indexed as

central precocious pubertymetabolic diseasemetachromatic leucodystrophyprecocious pubertywhite matter disease

Identifiers

PMID30197627
PMCPMC6117375
OpenAlexW2888759411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.