ArticleClinical interventions in aging2018
Glucocorticoid-induced delayed fracture healing and impaired bone biomechanical properties in mice.
Article in Clinical interventions in aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Fracture nonunion: classification, evaluation and management strategies-a structured approach for higher orthopaedic examinations.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Review
- Perioperative dexamethasone: Effects on length of stay, perioperative outcomes, and safety in isolated lower extremity long bone fracture fixation.Journal of clinical orthopaedics and trauma · 2025Article
- A Novel Method to Assess Healing of Segmental Bone Defects using the Induced Membrane Technique.Orthopaedic surgery · 2024Article
- Three predictive scores compared in a retrospective multicenter study of nonunion tibial shaft fracture.World journal of orthopedics · 2024Article
- Proteomic meta-study harmonization, mechanotyping and drug repurposing candidate prediction with ProHarMeD.NPJ systems biology and applications · 2023Article
- Nonpathological inflammation drives the development of an avian flight adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Disorganization and Musculoskeletal Diseases: Novel Insights into the Enigma of Unexplained Bone Abnormalities and Fragility Fractures.Current osteoporosis reports · 2023Review
- Assessment of Bone Fracture Healing Using Micro-Computed Tomography.Journal of visualized experiments : JoVE · 2022Article
- Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence.Endocrine reviews · 2022Review
- Current Clinical Concepts: Management of Common Lumbar Spine Posterior Column Disorders in Young, Active Individuals.Journal of athletic training · 2022Article
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- Review
- Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice.Biomedicines · 2022Article
- Review
- Hemophagocytic Lymphohistiocytosis After Trauma Due to a Motor Vehicle Accident: A Case Report.Cureus · 2021Article
- Modulation of Macrophage Activity by Pulsed Electromagnetic Fields in the Context of Fracture Healing.Bioengineering (Basel, Switzerland) · 2021Article
- Article
- Bone Healing and Inflammation: Principles of Fracture and Repair.Seminars in plastic surgery · 2021Review
- Cannabidiol-Driven Alterations to Inflammatory Protein Landscape of Lipopolysaccharide-Activated MacrophagesCannabis and cannabinoid research · 2021Article
- Distinct Glucocorticoid Receptor Actions in Bone Homeostasis and Bone Diseases.Frontiers in endocrinology · 2021Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe objective of the study was to investigate the effects of glucocorticoid (GC) on the fracture healing process in a closed femur fracture mice model. MATERIALS AND
methodsForty 12-week-old female CD-1 mice were randomly allocated into four groups: healthy control and mice with prednisone exposure (oral gavage), 6 mg/kg/day (GC-L), 9 mg/kg/day (GC-M) and 12 mg/kg/day (GC-H). Three weeks after the initiation of prednisone dosing, closed femur fractures were created on prednisone-exposed mice and the healthy control. Prednisone administration was continued for 9 weeks post-fracture, and X-ray imaging was performed weekly to monitor the fracture healing process until the mice were euthanized. Necropsy was performed after 9 weeks and the fractured femurs were isolated and processed at necropsy for micro-CT and biomechanical property analysis. Another 20 mice (control and GC-H, 10 mice/group) were used for histology and micro-CT analysis at early time point (2-week post fracture) with continued prednisone exposure.
resultsThe results showed that oral administration of prednisone for 3 months in this strain of mice could inhibit endochondral ossification and delay the healing process, especially hard callus formation (woven bone) and bone remodeling during healing. It also could significantly decrease bone biomechanical properties.
conclusionLong-term GC administration leads to significantly delayed fracture healing and impaired bone biomechanical properties. This mouse model may be used to systematically study the cellular and molecular mechanisms underlying fracture healing with GC treatment background and may also be used to study the influence of different therapeutic interventions for bone fracture healing.
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Registered trials
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