Observational studyThe Journal of pediatrics2018
Early Glycemic Profile Is Associated with Brain Injury Patterns on Magnetic Resonance Imaging in Hypoxic Ischemic Encephalopathy.
Observational study in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Risk factors for unfavorable outcome at discharge of newborns with hypoxic-ischemic encephalopathy in the era of hypothermia.Pediatric research · 2023Trial
- Hypothermia is not therapeutic in a neonatal piglet model of inflammation-sensitized hypoxia-ischemia.Pediatric research · 2022Trial
- Cumulative secondary systemic metabolic cerebral insults are associated with disease severity and mortality in neonatal hypoxic-ischaemic encephalopathy: a retrospective study.Frontiers in pediatrics · 2026Article
- Dextrose with Insulin During Neonatal Resuscitation for Prolonged Asphyxia in a Near-Term Ovine Model: A Proof-of-Concept Study.Children (Basel, Switzerland) · 2025Article
- Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Article
- Neonatal dysglycemia: a review of dysglycemia in relation to brain health and neurodevelopmental outcomes.Pediatric research · 2024Review
- Incidence of encephalopathy and comorbidity in infants with perinatal asphyxia: a comparative prospective cohort study.Frontiers in pediatrics · 2024Article
- Early Glycemic State and Outcomes of Neonates With Hypoxic-Ischemic Encephalopathy.Pediatrics · 2023Article
- Cerebral Effects of Neonatal Dysglycemia.Clinics in perinatology · 2022Review
- Thalamus L-Sign: A Potential Biomarker of Neonatal Partial, Prolonged Hypoxic-Ischemic Brain Injury or Hypoglycemic Encephalopathy?AJNR. American journal of neuroradiology · 2022Observational
- Expert consensus on the clinical practice of neonatal brain magnetic resonance imaging.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Impact of glucose metabolism on the developing brain.Frontiers in endocrinology · 2022Review
- Early Blood Glucose Level Post-Admission Correlates with the Outcomes and Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy.Antioxidants (Basel, Switzerland) · 2021Article
- Singapore Neonatal Resuscitation Guidelines 2021.Singapore medical journal · 2021Article
- Hyperglycemia associated with acute brain injury in neonatal encephalopathy.NeuroImage. Clinical · 2021Article
- Hyperglycaemia in the Newborn Infant. Physiology Verses Pathology.Frontiers in pediatrics · 2021Review
- [Newborn resuscitation and support of transition of infants at birth].Notfall & rettungsmedizin · 2021Review
- Neonatal Hypoglycemia and Brain Vulnerability.Frontiers in endocrinology · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate whether the early glycemic profile in infants with hypoxic ischemic encephalopathy is associated with distinct patterns of brain injury on magnetic resonance imaging (MRI). STUDY
designWe performed a secondary analysis of 178 prospectively enrolled infants who received therapeutic hypothermia for hypoxic ischemic encephalopathy. Glycemic profiles were identified by glucose concentrations within 24 hours after birth: normoglycemia (all glucose concentrations of >47 to ≤150 mg/dL; n = 62); hypoglycemia (≥1 concentration ≤47 mg/dL; n = 17); hyperglycemia (≥1 concentration >150 mg/dL; n = 76); and labile glucose (both hypoglycemia and hyperglycemia; n = 23). Patterns of brain injury were identified for 151 infants based on Barkovich scores from the postrewarming brain MRIs at a median age of 9 days.
resultsA normal brain MRI was reported in 37 of 62 infants (60%) with normal blood glucose values compared with 37 of 116 infants (32%) with an abnormal glucose profile (adjusted for Sarnat stage of encephalopathy and Apgar score at 5 minutes; P = .02). The distribution of MRI patterns of brain injury differed among the glycemic groups (P = .03). The odds of predominant watershed or focal-multifocal injury was higher in infants with hypoglycemia (aOR, 6; 95% CI, 1.5-24.2) and labile glucose (6.6; 95% CI, 1.6-27) compared with infants with normoglycemia. Infants with labile glucose had higher odds (5.6; 95% CI, 1.1-29.3) of predominant basal ganglia or global injury compared with infants with normal blood glucose values.
conclusionsThe early glycemic profile in infants with hypoxic ischemic encephalopathy is associated with specific patterns of brain injury on MRI. Further investigation is needed to explore its prognostic significance and role as a phenotype biomarker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.