Evidence map›Paper›PMID 30197041›Full record

Trial reportEuropean urology focus2018

A Randomized, Double-blind, Phase II Trial of PSA-TRICOM (PROSTVAC) in Patients with Localized Prostate Cancer: The Immunotherapy to Prevent Progression on Active Surveillance Study.

J Kellogg Parsons, Peter A Pinto, Christian P Pavlovich, Edward Uchio, Hyung L Kim, Mikel N Nguyen, James L Gulley, Christina Jamieson, Paul Hsu, Margarita Wojtowicz and 6 more

Open access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in European urology focus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Vaccines as treatments for prostate cancer.Nature reviews. Urology · 2023
    Review
  6. Article
  7. Oncolyic Virotherapy for Prostate Cancer: Lighting a Fire in Winter.International journal of molecular sciences · 2022
    Review
  8. Review
  9. Review
  10. Vaccines for Non-Viral Cancer Prevention.International journal of molecular sciences · 2021
    Review
  11. Review
  12. Clinical CAR-T Cell and Oncolytic Virotherapy for Cancer Treatment.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

J Kellogg ParsonsDepartment of Urology, UC San Diego Moores Cancer Center, La Jolla, CA, USA. Electronic address: jkparsons@ucsd.edu.
Peter A PintoNational Cancer Institute, Bethesda, MD, USA.
Christian P PavlovichDepartment of Urology, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.
Edward UchioDepartment of Urology, UC Irvine, Orange, CA, USA.
Hyung L KimDivision of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mikel N NguyenDepartment of Urology, University of Southern California, Los Angeles, CA, USA.
James L GulleyNational Cancer Institute, Bethesda, MD, USA.
Christina JamiesonDepartment of Urology, UC San Diego Moores Cancer Center, La Jolla, CA, USA.
Paul HsuUniversity of Arizona Cancer Center, Tucson, AZ, USA.
Margarita WojtowiczNational Cancer Institute, Bethesda, MD, USA.
Howard ParnesNational Cancer Institute, Bethesda, MD, USA.
Jeffrey SchlomNational Cancer Institute, Bethesda, MD, USA.
William L DahutNational Cancer Institute, Bethesda, MD, USA.
Ravi A MadanNational Cancer Institute, Bethesda, MD, USA.
Renee N DonahueNational Cancer Institute, Bethesda, MD, USA.
H-H Sherry ChowUniversity of Arizona Cancer Center, Tucson, AZ, USA.
National Cancer Institute · USUniversity of Arizona · USCedars-Sinai Medical Center · USJohns Hopkins University · USUC San Diego Health System · USUniversity of California, Irvine · USUniversity of California San Diego · USUniversity of Southern California · US

Funding

Prostate SectionZIABC011081 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PINTO, PETER · 2009 to 2025
$15.2M
NCI NIH HHS HHSN261201200001INCI NIH HHS HHSN261201200003INCI NIH HHS HHSN261201200031I
6 · The paper itself

Abstract

The Immunotherapy to Prevent Progression on Active Surveillance Study is the first trial of immunotherapy for localized prostate cancer. We randomized active surveillance patients to PSA-TRICOM (PROSTVAC) or placebo for 5mo. Final results will be available in 2019.

Indexed as

AgedCancer VaccinesDisease ProgressionFollow-Up StudiesHumansImmunologic FactorsImmunotherapyMaleMiddle AgedNeoplasm GradingProstate-Specific AntigenProstatic NeoplasmsTreatment OutcomeCancer VaccinesImmunologic FactorsProstate-Specific AntigenPROSTVAC

Identifiers

PMID30197041
PMCPMC7524340
OpenAlexW2891227337

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.