ArticleJournal of neuroimmunology2018
Variability in PolyIC induced immune response: Implications for preclinical maternal immune activation models.
Article in Journal of neuroimmunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Toll like receptor agonist effects on human CD8+ T cell activation and expression of T cell checkpoint receptors.Human vaccines & immunotherapeutics · 2025Article
- Mesenchymal stem cell-derived extracellular vesicles alleviate autism by regulating microglial glucose metabolism reprogramming and neuroinflammation through PD-1/PD-L1 interaction.Journal of nanobiotechnology · 2025Article
- Differential effects of purified low molecular weight Poly(I:C) in the maternal immune activation model depend on the laboratory environment.Translational psychiatry · 2024Article
- Immune synaptopathies: how maternal immune activation impacts synaptic function during development.The EMBO journal · 2023Review
- Influences of the Immune System and Microbiome on the Etiology of ASD and GI Symptomology of Autistic Individuals.Current topics in behavioral neurosciences · 2023Article
- Investigating behavioral phenotypes related to autism spectrum disorder in a gene-environment interaction model ofFrontiers in neuroscience · 2023Article
- Sources and Translational Relevance of Heterogeneity in Maternal Immune Activation Models.Current topics in behavioral neurosciences · 2023Review
- Glucocorticoid receptor dysregulation underlies 5-HTThe Journal of biological chemistry · 2022Article
- Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth.Clinical science (London, England : 1979) · 2022Article
- Interleukin 15 modulates the effects of poly I:C maternal immune activation on offspring behaviour.Brain, behavior, & immunity - health · 2022Article
- Maternal immune activation accelerates puberty initiation and alters mechanical allodynia in male and female C57BL6/J mice.Developmental psychobiology · 2022Article
- An Optimized Direct Lysis Gene Expression Microplate Assay and Applications for Disease, Differentiation, and Pharmacological Cell-Based Studies.Biosensors · 2022Article
- Increased alcohol self-administration following repeated Toll-like receptor 3 agonist treatment in male and female rats.Pharmacology, biochemistry, and behavior · 2022Article
- Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness.Journal of neuroinflammation · 2022Article
- A comprehensive approach to modeling maternal immune activation in rodents.Frontiers in neuroscience · 2022Review
- Immunomodulatory effects of new phytotherapy on human macrophages and TLR4- and TLR7/8-mediated viral-like inflammation in mice.Frontiers in medicine · 2022Article
- Article
- Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age.Brain, behavior, and immunity · 2021Article
- Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age.bioRxiv : the preprint server for biology · 2021Article
- Sensory filtering disruption caused by poly I:C - Timing of exposure and other experimental considerations.Brain, behavior, & immunity - health · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Maternal infection during pregnancy may increase the risk of offspring neurodevelopmental disorders. The preclinical Polyinosinic-polycytidylic acid (PolyIC) model has become one of the most widely used approaches in maternal immune activation (MIA) research. However, variability in molecular weight may impact the immune activating potential of PolyIC. Nulliparous rats injected with high molecular weight PolyIC exhibit pronounced cytokine response and sickness behavior that was not observed in rats injected low molecular weight PolyIC. Although an essential next step is to extend these studies to pregnant animals, the preliminary results suggest that PolyIC molecular weight is an important experimental design consideration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.