ArticleThe EMBO journal1986
Structural and functional dissection of an MHC class I antigen-binding adenovirus glycoprotein.
Article in The EMBO journal, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 87 citations in OpenAlex.
- An interaction between β'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.The Journal of cell biology · 2023Article
- The transmembrane domain of the adenovirus E3/19K protein acts as an endoplasmic reticulum retention signal and contributes to intracellular sequestration of major histocompatibility complex class I molecules.Journal of virology · 2013Article
- Molecular basis for recognition of dilysine trafficking motifs by COPI.Developmental cell · 2012Article
- Determinants of the endoplasmic reticulum (ER) lumenal-domain of the adenovirus serotype 2 E3-19K protein for association with and ER-retention of major histocompatibility complex class I molecules.Molecular immunology · 2011Article
- The endoplasmic reticulum lumenal domain of the adenovirus type 2 E3-19K protein binds to peptide-filled and peptide-deficient HLA-A*1101 molecules.Journal of virology · 2005Article
- Quantitative ER <--> Golgi transport kinetics and protein separation upon Golgi exit revealed by vesicular integral membrane protein 36 dynamics in live cells.Molecular biology of the cell · 2001Article
- The luminal part of the murine cytomegalovirus glycoprotein gp40 catalyzes the retention of MHC class I molecules.The EMBO journal · 2000Article
- Review
- Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells.The Journal of cell biology · 1999Article
- Specific down-regulation of annexin II expression in human cells interferes with cell proliferation.Molecular and cellular biochemistry · 1999Article
- Recycling of golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering.The Journal of cell biology · 1998Article
- gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer.The Journal of cell biology · 1998Article
- A sorting motif localizes the foamy virus glycoprotein to the endoplasmic reticulum.Journal of virology · 1997Article
- Early region 3 of adenovirus type 19 (subgroup D) encodes an HLA-binding protein distinct from that of subgroups B and C.Journal of virology · 1996Article
- Molecular mechanisms of class I major histocompatibility complex antigen processing and presentation.Immunologic research · 1996Review
- Cell cycle regulation of human WEE1.The EMBO journal · 1995Article
- Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.The Journal of cell biology · 1995Article
- Conserved cysteine residues within the E3/19K protein of adenovirus type 2 are essential for binding to major histocompatibility complex antigens.Journal of virology · 1994Article
- Article
- Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.The EMBO journal · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early transmembrane glycoprotein E19 of adenovirus-2 binds to class I antigens of the major histocompatibility complex (MHC). The association is initiated in the endoplasmic reticulum of infected cells and abrogates the intracellular transport of the class I molecules. To examine which parts of the E19 molecule are responsible for the association with the class I antigens and which parts confine the protein to the endoplasmic reticulum we have constructed a series of mutated E19 genes, which have been expressed in an improved mammalian expression vector. By various manipulations the membrane anchoring and the cytoplasmic domains were removed from the protein. The biosynthesis of the mutant protein was examined. All mutant proteins were secreted from the cells suggesting that the transmembrane and/or cytoplasmic portions of the E19 molecule are responsible for its confinement to the endoplasmic reticulum. The ability to associate with class I antigens was retained by the lumenal domain of the E19 protein.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.